Loss of CFTR function is associated with reduced bitter taste receptor-stimulated nitric oxide innate immune responses in nasal epithelial cells and macrophages

INTRODUCTION: Bitter taste receptors (T2Rs) are G protein-coupled receptors identified on the tongue but expressed all over the body, including in airway cilia and macrophages, where T2Rs serve an immune role. T2R isoforms detect bitter metabolites (quinolones and acyl-homoserine lactones) secreted...

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Detalles Bibliográficos
Autores principales: Carey, Ryan M., Palmer, James N., Adappa, Nithin D., Lee, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890060/
https://www.ncbi.nlm.nih.gov/pubmed/36742335
http://dx.doi.org/10.3389/fimmu.2023.1096242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890060/
https://www.ncbi.nlm.nih.gov/pubmed/36742335
http://dx.doi.org/10.3389/fimmu.2023.1096242

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