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High-Throughput Functional Evaluation of MAP2K1 Variants in Cancer

Activating mutations in mitogen-activated protein kinase kinase 1 (MAP2K1) are involved in a variety of cancers and may be classified according to their RAF dependence. Sensitivity to combined BRAF and MEK treatments is associated with co-mutations of MAP2K1 and BRAF; however, the significance of le...

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Detalles Bibliográficos
Autores principales:	Mizuno, Sho, Ikegami, Masachika, Koyama, Takafumi, Sunami, Kuniko, Ogata, Dai, Kage, Hidenori, Yanagaki, Mitsuru, Ikeuchi, Hiroshi, Ueno, Toshihide, Tanikawa, Michihiro, Oda, Katsutoshi, Osuga, Yutaka, Mano, Hiroyuki, Kohsaka, Shinji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Small Molecule Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890140/ https://www.ncbi.nlm.nih.gov/pubmed/36442478 http://dx.doi.org/10.1158/1535-7163.MCT-22-0302

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