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Affinity of cefotiam for the alternative penicillin binding protein PBP3(SAL) used by Salmonella inside host eukaryotic cells

BACKGROUND: Following the invasion of eukaryotic cells, Salmonella enterica serovar Typhimurium replaces PBP2/PBP3, main targets of β-lactam antibiotics, with PBP2(SAL)/PBP3(SAL), two homologue peptidoglycan synthases absent in Escherichia coli. PBP3(SAL) promotes pathogen cell division in acidic en...

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Detalles Bibliográficos
Autores principales:	Cestero, Juan J, Castanheira, Sónia, González, Henar, Zaragoza, Óscar, García-del Portillo, Francisco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890219/ https://www.ncbi.nlm.nih.gov/pubmed/36512374 http://dx.doi.org/10.1093/jac/dkac422

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