Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-analysis

RATIONALE: Methylation integrates factors present at birth and modifiable across the lifespan that can influence pulmonary function. Studies are limited in scope and replication. OBJECTIVES: To conduct large-scale epigenome-wide meta-analyses of blood DNA methylation and pulmonary function. METHODS:...

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Detalles Bibliográficos
Autores principales: Lee, Mikyeong, Huan, Tianxiao, McCartney, Daniel L., Chittoor, Geetha, de Vries, Maaike, Lahousse, Lies, Nguyen, Jennifer N., Brody, Jennifer A., Castillo-Fernandez, Juan, Terzikhan, Natalie, Qi, Cancan, Joehanes, Roby, Min, Josine L., Smilnak, Gordon J., Shaw, Jessica R., Yang, Chen Xi, Colicino, Elena, Hoang, Thanh T., Bermingham, Mairead L., Xu, Hanfei, Justice, Anne E., Xu, Cheng-Jian, Rich, Stephen S., Cox, Simon R., Vonk, Judith M., Prokić, Ivana, Sotoodehnia, Nona, Tsai, Pei-Chien, Schwartz, Joel D., Leung, Janice M., Sikdar, Sinjini, Walker, Rosie M., Harris, Sarah E., van der Plaat, Diana A., Van Den Berg, David J., Bartz, Traci M., Spector, Tim D., Vokonas, Pantel S., Marioni, Riccardo E., Taylor, Adele M., Liu, Yongmei, Barr, R. Graham, Lange, Leslie A., Baccarelli, Andrea A., Obeidat, Ma’en, Fornage, Myriam, Wang, Tianyuan, Ward, James M., Motsinger-Reif, Alison A., Hemani, Gibran, Koppelman, Gerard H., Bell, Jordana T., Gharib, Sina A., Brusselle, Guy, Boezen, H. Marike, North, Kari E., Levy, Daniel, Evans, Kathryn L., Dupuis, Josée, Breeze, Charles E., Manichaikul, Ani, London, Stephanie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Thoracic Society 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890261/
https://www.ncbi.nlm.nih.gov/pubmed/35536696
http://dx.doi.org/10.1164/rccm.202108-1907OC

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