Revisiting the Problem of Finding Effective Sepsis Treatment Solutions

We studied the effect of a preparation containing ultralow doses of formic aldehyde on the course of experimental sepsis caused by intraperitoneal injection of two different strains of Pseudomonas aeruginosa (1623 and 5266) to C57BL/6 male mice. Microscopy and quantitative bacteriological tests in the dynamics of the infectious process demonstrated a positive effect of the drug: 100% survival of animals, preserved histological structure of the studied organs (lungs, liver, kidneys, spleen, and adrenal glands), a sharp decrease in the level of contamination of the blood and organ homogenates during the first hours after infection, and complete absence of bacteria in inoculates on day 7 after infection. These findings suggest the effectiveness of ultralow doses of formic acid aldehyde in the composition of the medicinal product in the treatment of experimental sepsis caused by P. aeruginosa strains 1623 and 5266 in mice.