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Flexible doctor blade-coated abiotic cathodes for implantable glucose/oxygen biofuel cells

Implantable devices powered by batteries have been used for sixty years. In recent devices, lithium-based batteries are the most widely used power source. However, lithium batteries have many disadvantages in terms of safety, reliability, and longevity and require regular monitoring and substitution...

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Autores principales: Ghodhbane, Myriam, Menassol, Gauthier, Beneventi, Davide, Chaussy, Didier, Dubois, Lionel, Zebda, Abdelkader, Belgacem, Mohamed Naceur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890629/
https://www.ncbi.nlm.nih.gov/pubmed/36756603
http://dx.doi.org/10.1039/d2ra03471a
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author Ghodhbane, Myriam
Menassol, Gauthier
Beneventi, Davide
Chaussy, Didier
Dubois, Lionel
Zebda, Abdelkader
Belgacem, Mohamed Naceur
author_facet Ghodhbane, Myriam
Menassol, Gauthier
Beneventi, Davide
Chaussy, Didier
Dubois, Lionel
Zebda, Abdelkader
Belgacem, Mohamed Naceur
author_sort Ghodhbane, Myriam
collection PubMed
description Implantable devices powered by batteries have been used for sixty years. In recent devices, lithium-based batteries are the most widely used power source. However, lithium batteries have many disadvantages in terms of safety, reliability, and longevity and require regular monitoring and substitution. Implantable glucose biofuel cells (BFCs) are increasingly seen as a potential future technology for replacing lithium-based batteries because they do not require surgical replacement after 8–10 years and have a theoretically unlimited lifetime thanks to the continued recovery of glucose and oxygen present in the human body. This paper shows the fabrication of flexible implantable abiotic cathodes, based on a nitrogen/iron-doped graphene catalyst, for glucose/oxygen biofuel cell application. An ink, based on nitrogen-iron doped graphene as the abiotic catalyst and chitosan as a binder, was prepared and coated on a flexible teflonated gas diffusion layer using doctor blade coating. The characterization of the biocathode shows an open potential circuit corresponding to the potential of the abiotic catalyst and a high oxygen reduction current density of up to 66 μA cm(−2) under physiological conditions. Those cathodes remain stable for up to two years with a current density loss of only 25%. The flexible abiotic electrode cytotoxicity was evaluated by cell culture experiments showing living cells' high tolerance on the biocathode surface. This work demonstrates that this abiotic catalyst can be a promising alternative for the development of implantable glucose BFCs due to its stability and its cytocompatibility.
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spelling pubmed-98906292023-02-07 Flexible doctor blade-coated abiotic cathodes for implantable glucose/oxygen biofuel cells Ghodhbane, Myriam Menassol, Gauthier Beneventi, Davide Chaussy, Didier Dubois, Lionel Zebda, Abdelkader Belgacem, Mohamed Naceur RSC Adv Chemistry Implantable devices powered by batteries have been used for sixty years. In recent devices, lithium-based batteries are the most widely used power source. However, lithium batteries have many disadvantages in terms of safety, reliability, and longevity and require regular monitoring and substitution. Implantable glucose biofuel cells (BFCs) are increasingly seen as a potential future technology for replacing lithium-based batteries because they do not require surgical replacement after 8–10 years and have a theoretically unlimited lifetime thanks to the continued recovery of glucose and oxygen present in the human body. This paper shows the fabrication of flexible implantable abiotic cathodes, based on a nitrogen/iron-doped graphene catalyst, for glucose/oxygen biofuel cell application. An ink, based on nitrogen-iron doped graphene as the abiotic catalyst and chitosan as a binder, was prepared and coated on a flexible teflonated gas diffusion layer using doctor blade coating. The characterization of the biocathode shows an open potential circuit corresponding to the potential of the abiotic catalyst and a high oxygen reduction current density of up to 66 μA cm(−2) under physiological conditions. Those cathodes remain stable for up to two years with a current density loss of only 25%. The flexible abiotic electrode cytotoxicity was evaluated by cell culture experiments showing living cells' high tolerance on the biocathode surface. This work demonstrates that this abiotic catalyst can be a promising alternative for the development of implantable glucose BFCs due to its stability and its cytocompatibility. The Royal Society of Chemistry 2023-01-27 /pmc/articles/PMC9890629/ /pubmed/36756603 http://dx.doi.org/10.1039/d2ra03471a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Ghodhbane, Myriam
Menassol, Gauthier
Beneventi, Davide
Chaussy, Didier
Dubois, Lionel
Zebda, Abdelkader
Belgacem, Mohamed Naceur
Flexible doctor blade-coated abiotic cathodes for implantable glucose/oxygen biofuel cells
title Flexible doctor blade-coated abiotic cathodes for implantable glucose/oxygen biofuel cells
title_full Flexible doctor blade-coated abiotic cathodes for implantable glucose/oxygen biofuel cells
title_fullStr Flexible doctor blade-coated abiotic cathodes for implantable glucose/oxygen biofuel cells
title_full_unstemmed Flexible doctor blade-coated abiotic cathodes for implantable glucose/oxygen biofuel cells
title_short Flexible doctor blade-coated abiotic cathodes for implantable glucose/oxygen biofuel cells
title_sort flexible doctor blade-coated abiotic cathodes for implantable glucose/oxygen biofuel cells
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890629/
https://www.ncbi.nlm.nih.gov/pubmed/36756603
http://dx.doi.org/10.1039/d2ra03471a
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