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Towards the use of an amino acid cleavable linker for solid-phase chemical synthesis of peptides and proteins
The synthesis of proteins by solid-phase chemical ligation (SPCL) suffers from the paucity of linkers that can be cleaved under mild conditions. Here, we deployed a spontaneous nickel-assisted cleavage (SNAC) tag, known to undergo spontaneous cleavage in the presence of nickel(ii), as a linker for C...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890637/ https://www.ncbi.nlm.nih.gov/pubmed/36628630 http://dx.doi.org/10.1039/d2ob02198f |