Zn(0.4)Mg(0.6)Fe(2)O(4) nanoenzyme: a novel chemo-sensitizer for the chemotherapy treatment of oral squamous cell carcinoma

Hypoxic and acidic environments are the two main components of the microenvironment contributing to the poor efficacy of chemotherapy drugs in the treatment of oral squamous cell carcinoma (OSCC). In this study, we synthesized a series of Zn(1–x)Mg(x)Fe(2)O(4) nanomaterials with enzyme-like properti...

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Detalles Bibliográficos
Autores principales: Chen, Liang, Kong, Qingmei, Tian, Mingxing, Zhang, Qian, Xia, Chengwan, Deng, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890649/
https://www.ncbi.nlm.nih.gov/pubmed/36756528
http://dx.doi.org/10.1039/d2na00750a
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author Chen, Liang
Kong, Qingmei
Tian, Mingxing
Zhang, Qian
Xia, Chengwan
Deng, Chao
author_facet Chen, Liang
Kong, Qingmei
Tian, Mingxing
Zhang, Qian
Xia, Chengwan
Deng, Chao
author_sort Chen, Liang
collection PubMed
description Hypoxic and acidic environments are the two main components of the microenvironment contributing to the poor efficacy of chemotherapy drugs in the treatment of oral squamous cell carcinoma (OSCC). In this study, we synthesized a series of Zn(1–x)Mg(x)Fe(2)O(4) nanomaterials with enzyme-like properties, including catalase (CAT)-like, peroxidase (POD)-like, and glutathione (GSH)-like activity in an acidic environment. Among them, Zn(0.4)Mg(0.6)Fe(2)O(4) performed the best and effectively increased the efficacy of doxorubicin (DOX) chemotherapy for the treatment of OSCC with reduced cardiotoxicity. Therefore, Zn(0.4)Mg(0.6)Fe(2)O(4) could serve as a novel chemosensitizer in the treatment of OSCC.
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spelling pubmed-98906492023-02-07 Zn(0.4)Mg(0.6)Fe(2)O(4) nanoenzyme: a novel chemo-sensitizer for the chemotherapy treatment of oral squamous cell carcinoma Chen, Liang Kong, Qingmei Tian, Mingxing Zhang, Qian Xia, Chengwan Deng, Chao Nanoscale Adv Chemistry Hypoxic and acidic environments are the two main components of the microenvironment contributing to the poor efficacy of chemotherapy drugs in the treatment of oral squamous cell carcinoma (OSCC). In this study, we synthesized a series of Zn(1–x)Mg(x)Fe(2)O(4) nanomaterials with enzyme-like properties, including catalase (CAT)-like, peroxidase (POD)-like, and glutathione (GSH)-like activity in an acidic environment. Among them, Zn(0.4)Mg(0.6)Fe(2)O(4) performed the best and effectively increased the efficacy of doxorubicin (DOX) chemotherapy for the treatment of OSCC with reduced cardiotoxicity. Therefore, Zn(0.4)Mg(0.6)Fe(2)O(4) could serve as a novel chemosensitizer in the treatment of OSCC. RSC 2022-12-28 /pmc/articles/PMC9890649/ /pubmed/36756528 http://dx.doi.org/10.1039/d2na00750a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Chen, Liang
Kong, Qingmei
Tian, Mingxing
Zhang, Qian
Xia, Chengwan
Deng, Chao
Zn(0.4)Mg(0.6)Fe(2)O(4) nanoenzyme: a novel chemo-sensitizer for the chemotherapy treatment of oral squamous cell carcinoma
title Zn(0.4)Mg(0.6)Fe(2)O(4) nanoenzyme: a novel chemo-sensitizer for the chemotherapy treatment of oral squamous cell carcinoma
title_full Zn(0.4)Mg(0.6)Fe(2)O(4) nanoenzyme: a novel chemo-sensitizer for the chemotherapy treatment of oral squamous cell carcinoma
title_fullStr Zn(0.4)Mg(0.6)Fe(2)O(4) nanoenzyme: a novel chemo-sensitizer for the chemotherapy treatment of oral squamous cell carcinoma
title_full_unstemmed Zn(0.4)Mg(0.6)Fe(2)O(4) nanoenzyme: a novel chemo-sensitizer for the chemotherapy treatment of oral squamous cell carcinoma
title_short Zn(0.4)Mg(0.6)Fe(2)O(4) nanoenzyme: a novel chemo-sensitizer for the chemotherapy treatment of oral squamous cell carcinoma
title_sort zn(0.4)mg(0.6)fe(2)o(4) nanoenzyme: a novel chemo-sensitizer for the chemotherapy treatment of oral squamous cell carcinoma
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890649/
https://www.ncbi.nlm.nih.gov/pubmed/36756528
http://dx.doi.org/10.1039/d2na00750a
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