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Platelet P2Y(1) receptor exhibits constitutive G protein signaling and β-arrestin 2 recruitment

BACKGROUND: Purinergic P2Y(1) and P2Y(12) receptors (P2Y(1)-R and P2Y(12)-R) are G protein-coupled receptors (GPCR) activated by adenosine diphosphate (ADP) to mediate platelet activation, thereby playing a pivotal role in hemostasis and thrombosis. While P2Y(12)-R is the major target of antiplatele...

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Detalles Bibliográficos
Autores principales:	Ribes, Agnès, Garcia, Cédric, Gratacap, Marie-Pierre, Kostenis, Evi, Martinez, Laurent O., Payrastre, Bernard, Sénard, Jean-Michel, Galés, Céline, Pons, Véronique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890698/ https://www.ncbi.nlm.nih.gov/pubmed/36721118 http://dx.doi.org/10.1186/s12915-023-01528-y

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