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Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α(2)-adrenergic receptor competitive antagonist in combination with caffeine
BACKGROUND: The α(2) adrenergic receptor agonist dexmedetomidine is an important intravenous sedative with analgesic properties. Currently available dexmedetomidine reversal agents, like the α(2)-receptor antagonist atipamezole, cause serious adverse effects at the large dosages required for effecti...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890710/ https://www.ncbi.nlm.nih.gov/pubmed/36721095 http://dx.doi.org/10.1186/s12871-023-01986-5 |