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Refractory ventricular tachycardia and heart failure due to anti-mitochondrial antibody-positive inflammatory myopathy

BACKGROUND: Anti-mitochondrial antibody (AMA)-positive inflammatory myopathy, a rare type of idiopathic inflammatory myopathy which was frequently difficult to diagnose, can affect muscles and the structure and electrical conduction of the heart. Early identification and treatment of this myopathy c...

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Autores principales: Huang, Rong, Zhang, Xinlin, Han, Zhonglin, Wu, Xiang, Li, Guannan, Chen, Jianzhou, Xu, Biao, Gu, Rong, Wang, Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890839/
https://www.ncbi.nlm.nih.gov/pubmed/36721091
http://dx.doi.org/10.1186/s12872-023-03057-6
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author Huang, Rong
Zhang, Xinlin
Han, Zhonglin
Wu, Xiang
Li, Guannan
Chen, Jianzhou
Xu, Biao
Gu, Rong
Wang, Lian
author_facet Huang, Rong
Zhang, Xinlin
Han, Zhonglin
Wu, Xiang
Li, Guannan
Chen, Jianzhou
Xu, Biao
Gu, Rong
Wang, Lian
author_sort Huang, Rong
collection PubMed
description BACKGROUND: Anti-mitochondrial antibody (AMA)-positive inflammatory myopathy, a rare type of idiopathic inflammatory myopathy which was frequently difficult to diagnose, can affect muscles and the structure and electrical conduction of the heart. Early identification and treatment of this myopathy can prevent serious cardiovascular adverse events and improve cardiac function. CASE PRESENTATION: We report a patient who experienced repeated syncope, ventricular tachycardia (VT) and heart failure accompanied by weakness and muscle atrophy. He was initially diagnosed with dilated cardiomyopathy and received implantable cardioverter-defibrillator therapy. He was subsequently misdiagnosed as muscular dystrophy due to progressive muscular atrophy. However, the patient developed repeated and refractory VT storms that were not alleviated by conventional therapy. Finally, he was diagnosed with AMA-positive inflammatory myopathy with cardiac injuries. The patient was markedly recovered by being treated with immunosuppressive and immunomodulatory therapy. CONCLUSION: AMA could be screened when discovering myopathies accompanied by unexplained cardiac symptoms. Our findings provide insights into the diagnosis and therapy of this rare and severe disease.
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spelling pubmed-98908392023-02-02 Refractory ventricular tachycardia and heart failure due to anti-mitochondrial antibody-positive inflammatory myopathy Huang, Rong Zhang, Xinlin Han, Zhonglin Wu, Xiang Li, Guannan Chen, Jianzhou Xu, Biao Gu, Rong Wang, Lian BMC Cardiovasc Disord Case Report BACKGROUND: Anti-mitochondrial antibody (AMA)-positive inflammatory myopathy, a rare type of idiopathic inflammatory myopathy which was frequently difficult to diagnose, can affect muscles and the structure and electrical conduction of the heart. Early identification and treatment of this myopathy can prevent serious cardiovascular adverse events and improve cardiac function. CASE PRESENTATION: We report a patient who experienced repeated syncope, ventricular tachycardia (VT) and heart failure accompanied by weakness and muscle atrophy. He was initially diagnosed with dilated cardiomyopathy and received implantable cardioverter-defibrillator therapy. He was subsequently misdiagnosed as muscular dystrophy due to progressive muscular atrophy. However, the patient developed repeated and refractory VT storms that were not alleviated by conventional therapy. Finally, he was diagnosed with AMA-positive inflammatory myopathy with cardiac injuries. The patient was markedly recovered by being treated with immunosuppressive and immunomodulatory therapy. CONCLUSION: AMA could be screened when discovering myopathies accompanied by unexplained cardiac symptoms. Our findings provide insights into the diagnosis and therapy of this rare and severe disease. BioMed Central 2023-01-31 /pmc/articles/PMC9890839/ /pubmed/36721091 http://dx.doi.org/10.1186/s12872-023-03057-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Huang, Rong
Zhang, Xinlin
Han, Zhonglin
Wu, Xiang
Li, Guannan
Chen, Jianzhou
Xu, Biao
Gu, Rong
Wang, Lian
Refractory ventricular tachycardia and heart failure due to anti-mitochondrial antibody-positive inflammatory myopathy
title Refractory ventricular tachycardia and heart failure due to anti-mitochondrial antibody-positive inflammatory myopathy
title_full Refractory ventricular tachycardia and heart failure due to anti-mitochondrial antibody-positive inflammatory myopathy
title_fullStr Refractory ventricular tachycardia and heart failure due to anti-mitochondrial antibody-positive inflammatory myopathy
title_full_unstemmed Refractory ventricular tachycardia and heart failure due to anti-mitochondrial antibody-positive inflammatory myopathy
title_short Refractory ventricular tachycardia and heart failure due to anti-mitochondrial antibody-positive inflammatory myopathy
title_sort refractory ventricular tachycardia and heart failure due to anti-mitochondrial antibody-positive inflammatory myopathy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890839/
https://www.ncbi.nlm.nih.gov/pubmed/36721091
http://dx.doi.org/10.1186/s12872-023-03057-6
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