Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology

BACKGROUND: The rare p.H157Y variant of TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) was found to increase Alzheimer’s disease (AD) risk. This mutation is located at the cleavage site of TREM2 extracellular domain. Ectopic expression of TREM2-H157Y in HEK293 cells resulted in increased T...

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Detalles Bibliográficos
Autores principales: Qiao, Wenhui, Chen, Yixing, Zhong, Jun, Madden, Benjamin J., Charlesworth, Cristine M., Martens, Yuka A., Liu, Chia-Chen, Knight, Joshua, Ikezu, Tadafumi C., Kurti, Aishe, Zhu, Yiyang, Meneses, Axel, Rosenberg, Cassandra L., Kuchenbecker, Lindsey A., Vanmaele, Lucy K., Li, Fuyao, Chen, Kai, Shue, Francis, Dacquel, Maxwell V., Fryer, John, Pandey, Akhilesh, Zhao, Na, Bu, Guojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890893/
https://www.ncbi.nlm.nih.gov/pubmed/36721205
http://dx.doi.org/10.1186/s13024-023-00599-3

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