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Oral Arginine Supplementation in Healthy Individuals Performing Regular Resistance Training

Resistance exercise training is well documented as having cardiovascular benefits, but paradoxically, it seems to increase arterial stiffness, favoring the development of high blood pressure. The present study investigates the potential effects of oral supplementation with arginine in healthy indivi...

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Autores principales: Busnatu, Ștefan-Sebastian, Andronic, Octavian, Pană, Maria-Alexandra, Stoian, Anca Pantea, Scafa-Udriște, Alexandru, Păun, Nicolae, Stanciu, Silviu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891176/
https://www.ncbi.nlm.nih.gov/pubmed/36673550
http://dx.doi.org/10.3390/healthcare11020182
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author Busnatu, Ștefan-Sebastian
Andronic, Octavian
Pană, Maria-Alexandra
Stoian, Anca Pantea
Scafa-Udriște, Alexandru
Păun, Nicolae
Stanciu, Silviu
author_facet Busnatu, Ștefan-Sebastian
Andronic, Octavian
Pană, Maria-Alexandra
Stoian, Anca Pantea
Scafa-Udriște, Alexandru
Păun, Nicolae
Stanciu, Silviu
author_sort Busnatu, Ștefan-Sebastian
collection PubMed
description Resistance exercise training is well documented as having cardiovascular benefits, but paradoxically, it seems to increase arterial stiffness, favoring the development of high blood pressure. The present study investigates the potential effects of oral supplementation with arginine in healthy individuals performing exercise resistance training. We studied 70 non-smoking male subjects between the ages of 30 and 45 with normal or mildly increased blood pressure on ambulatory monitoring (for 24 h) and normal blood samples and echocardiography, who performed regular resistance exercise training for at least five years with a minimum of three workouts per week. They were divided into two groups in a random manner: 35 males were placed in the arginine group (AG) that followed a 6-month supplementation of their regular diets with 5 g of oral arginine powder taken before their exercise workout, and the control (non-arginine) group (NAG) consisted of 35 males. All subjects underwent body composition analysis, 24 h blood pressure monitoring and pulse wave analysis at enrollment and at six months. After six months of supplementation, blood pressure values did not change in the NAG, while in the AG, we found a decrease of 5.6 mmHg (p < 0.05) in mean systolic blood pressure and a decrease of 4.5 mmHg (p < 0.05) in diastolic values. There was also a 0.62% increase in muscle mass in the AG vs. the NAG (p < 0.05), while the body fat decreased by 1% (p < 0.05 in AG vs. NAG). Overall, the AG gained twice the amount of muscle mass and lost twice as much body fat as the NAG. No effects on the mean weighted average heart rate were recorded in the subjects. The results suggest that oral supplementation with arginine can improve blood pressure and body composition, potentially counteracting the stress induced by resistance exercise training. Supplementation with arginine can be a suitable adjuvant for these health benefits in individuals undertaking regular resistance training.
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spelling pubmed-98911762023-02-02 Oral Arginine Supplementation in Healthy Individuals Performing Regular Resistance Training Busnatu, Ștefan-Sebastian Andronic, Octavian Pană, Maria-Alexandra Stoian, Anca Pantea Scafa-Udriște, Alexandru Păun, Nicolae Stanciu, Silviu Healthcare (Basel) Article Resistance exercise training is well documented as having cardiovascular benefits, but paradoxically, it seems to increase arterial stiffness, favoring the development of high blood pressure. The present study investigates the potential effects of oral supplementation with arginine in healthy individuals performing exercise resistance training. We studied 70 non-smoking male subjects between the ages of 30 and 45 with normal or mildly increased blood pressure on ambulatory monitoring (for 24 h) and normal blood samples and echocardiography, who performed regular resistance exercise training for at least five years with a minimum of three workouts per week. They were divided into two groups in a random manner: 35 males were placed in the arginine group (AG) that followed a 6-month supplementation of their regular diets with 5 g of oral arginine powder taken before their exercise workout, and the control (non-arginine) group (NAG) consisted of 35 males. All subjects underwent body composition analysis, 24 h blood pressure monitoring and pulse wave analysis at enrollment and at six months. After six months of supplementation, blood pressure values did not change in the NAG, while in the AG, we found a decrease of 5.6 mmHg (p < 0.05) in mean systolic blood pressure and a decrease of 4.5 mmHg (p < 0.05) in diastolic values. There was also a 0.62% increase in muscle mass in the AG vs. the NAG (p < 0.05), while the body fat decreased by 1% (p < 0.05 in AG vs. NAG). Overall, the AG gained twice the amount of muscle mass and lost twice as much body fat as the NAG. No effects on the mean weighted average heart rate were recorded in the subjects. The results suggest that oral supplementation with arginine can improve blood pressure and body composition, potentially counteracting the stress induced by resistance exercise training. Supplementation with arginine can be a suitable adjuvant for these health benefits in individuals undertaking regular resistance training. MDPI 2023-01-06 /pmc/articles/PMC9891176/ /pubmed/36673550 http://dx.doi.org/10.3390/healthcare11020182 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Busnatu, Ștefan-Sebastian
Andronic, Octavian
Pană, Maria-Alexandra
Stoian, Anca Pantea
Scafa-Udriște, Alexandru
Păun, Nicolae
Stanciu, Silviu
Oral Arginine Supplementation in Healthy Individuals Performing Regular Resistance Training
title Oral Arginine Supplementation in Healthy Individuals Performing Regular Resistance Training
title_full Oral Arginine Supplementation in Healthy Individuals Performing Regular Resistance Training
title_fullStr Oral Arginine Supplementation in Healthy Individuals Performing Regular Resistance Training
title_full_unstemmed Oral Arginine Supplementation in Healthy Individuals Performing Regular Resistance Training
title_short Oral Arginine Supplementation in Healthy Individuals Performing Regular Resistance Training
title_sort oral arginine supplementation in healthy individuals performing regular resistance training
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891176/
https://www.ncbi.nlm.nih.gov/pubmed/36673550
http://dx.doi.org/10.3390/healthcare11020182
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