Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer

CRISPR Cas9-based screening is a powerful approach for identifying and characterizing novel drug targets. Here, we elucidate the synthetic lethal mechanism of deubiquitinating enzyme USP1 in cancers with underlying DNA damage vulnerabilities, specifically BRCA1/2 mutant tumors and a subset of BRCA1/...

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Detalles Bibliográficos
Autores principales: Simoneau, Antoine, Engel, Justin L., Bandi, Madhavi, Lazarides, Katherine, Liu, Shangtao, Meier, Samuel R., Choi, Ashley H., Zhang, Hongxiang, Shen, Binzhang, Martires, Lauren, Gotur, Deepali, Pham, Truc V., Li, Fang, Gu, Lina, Gong, Shanzhong, Zhang, Minjie, Wilker, Erik, Pan, Xuewen, Whittington, Douglas A., Throner, Scott, Maxwell, John P., Chen, Yingnan, Yu, Yi, Huang, Alan, Andersen, Jannik N., Feng, Tianshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891357/
https://www.ncbi.nlm.nih.gov/pubmed/36228090
http://dx.doi.org/10.1158/1535-7163.MCT-22-0409

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