Cargando…

Upregulated expression of FFAR2 and SOC3 genes is associated with gout

OBJECTIVE: To examine the expression of Free fatty acid receptor 2 (FFAR2) and Suppressor of cytokine signalling 3 (SOCS3) genes in asymptomatic hyperuricaemia (AH), AH with MSU crystal deposition, inter-critical gout and gout flare. METHODS: Study participants (n = 120) comprised 34 people with ser...

Descripción completa

Detalles Bibliográficos
Autores principales:	Orji, Oliver C, López-Domínguez, Maria B, Sandoval-Plata, Gabriela, Guetta-Baranes, Tamar, Valdes, Ana M, Doherty, Michael, Morgan, Kevin, Abhishek, Abhishek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Basic Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891400/ https://www.ncbi.nlm.nih.gov/pubmed/35731142 http://dx.doi.org/10.1093/rheumatology/keac360

Ejemplares similares

Are polymorphisms affecting serum urate, renal urate handling and alcohol intake associated with co-morbidities in gout cases? A case–control study using data from the UK Biobank
por: Sandoval-Plata, Gabriela, et al.
Publicado: (2022)

Brief Report: Monosodium Urate Monohydrate Crystal Deposits Are Common in Asymptomatic Sons of Patients With Gout: The Sons of Gout Study
por: Abhishek, Abhishek, et al.
Publicado: (2018)

Triggers of acute attacks of gout, does age of gout onset matter? A primary care based cross-sectional study
por: Abhishek, Abhishek, et al.
Publicado: (2017)

Incident gout and erectile dysfunction: is hyperuricaemia the elephant in the room?
por: Abhishek, Abhishek, et al.
Publicado: (2017)

Gout Activity Score has predictive validity and is sensitive to change: results from the Nottingham Gout Treatment Trial (Phase II)
por: Chinchilla, Sandra P, et al.
Publicado: (2019)

Expression of FFAR3 and FFAR4 Is Increased in Gastroesophageal Reflux Disease
por: Fabisiak, Adam, et al.
Publicado: (2020)

Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression
por: Wang, Zhen, et al.
Publicado: (2022)

Complement receptor 1 gene (CR1) intragenic duplication and risk of Alzheimer’s disease
por: Kucukkilic, Ezgi, et al.
Publicado: (2018)

FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing
por: Ang, Zhiwei, et al.
Publicado: (2018)

Molecular characterization of free fatty acid receptors FFAR2 and FFAR3 in the domestic cat
por: Yamamoto, Ichiro, et al.
Publicado: (2020)

Observations of extensive gene expression differences in the cerebellum and potential relevance to Alzheimer’s disease
por: Chappell, Sally, et al.
Publicado: (2018)

Lipid-Sensing Receptor FFAR4 Modulates Pulmonary Epithelial Homeostasis following Immunogenic Exposures Independently of the FFAR4 Ligand Docosahexaenoic Acid (DHA)
por: Sveiven, Stefanie N., et al.
Publicado: (2023)

Optimization of First-in-Class Dual-Acting FFAR1/FFAR4 Allosteric Modulators with Novel Mode of Action
por: Lückmann, Michael, et al.
Publicado: (2022)

Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1
por: Gui, Yirui, et al.
Publicado: (2017)

Gout. Epidemiology of gout
por: Roddy, Edward, et al.
Publicado: (2010)

Omega-3 Fatty Acids and FFAR4
por: Oh, Da Young, et al.
Publicado: (2014)

Mechanistic Studies on the Stereoselectivity of FFAR1 Modulators
por: Teng, Dan, et al.
Publicado: (2022)

Molecular mechanism of fatty acid activation of FFAR1
por: Kumari, Punita, et al.
Publicado: (2023)

Effect of short chain fatty acids on the expression of free fatty acid receptor 2 (Ffar2), Ffar3 and early-stage adipogenesis
por: Frost, G, et al.
Publicado: (2014)

Circ_0003356 suppresses gastric cancer growth through targeting the miR-668-3p/SOCS3 axis
por: Li, Wei-Dong, et al.
Publicado: (2023)

Profiling of serum oxylipins identifies distinct spectrums and potential biomarkers in young people with very early onset gout
por: Wang, Can, et al.
Publicado: (2022)

Variants in the FFAR1 Gene Are Associated with Beta Cell Function
por: Kalis, Martins, et al.
Publicado: (2007)

Ffar2 expression regulates leukaemic cell growth in vivo
por: Bindels, Laure B, et al.
Publicado: (2017)

Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists
por: Ang, Zhiwei, et al.
Publicado: (2016)

Does FFAR4 Agonism have Therapeutic Potential in Cardiometabolic Disease?
por: Lay, Abigail C
Publicado: (2021)

Neutrophil microvesicles resolve gout by inhibiting C5a-mediated priming of the inflammasome
por: Cumpelik, Arun, et al.
Publicado: (2016)

Respiratory Syncytial Virus Nonstructural Proteins Upregulate SOCS1 and SOCS3 in the Different Manner from Endogenous IFN Signaling
por: Zheng, Junwen, et al.
Publicado: (2015)

Feasibility of conducting a randomized, placebo-controlled study assessing whether omega-3 fatty acids prevent gout flares when starting urate-lowering treatment
por: Abhishek, Abhishek, et al.
Publicado: (2022)

Systemic overexpression of interleukin-22 induces the negative immune-regulator SOCS3 and potently reduces experimental arthritis in mice
por: Aarts, Joyce, et al.
Publicado: (2020)

Upregulation of SCUBE1 in Dengue Virus Infection
por: Ali, Hirowati, et al.
Publicado: (2019)

40008 COMBINED CRISPR/CAS9 AND AAV FOR THE GENERATION OF CONDITIONAL ISOGENIC GENE KNOCK-INS
por: Boddu, Prajwal, et al.
Publicado: (2021)

Reasons for discontinuing urate-lowering treatment in community-dwelling adults with gout: results of a primary care-based cross-sectional study
por: Elmelegy, Dalia, et al.
Publicado: (2021)

Expression of Interleukin-26 is upregulated in inflammatory bowel disease
por: Fujii, Makoto, et al.
Publicado: (2017)

Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice
por: Nakamoto, Kazuo, et al.
Publicado: (2017)

Free Fatty Acid Receptors (FFARs) in Adipose: Physiological Role and Therapeutic Outlook
por: Al Mahri, Saeed, et al.
Publicado: (2022)

FFAR from the Gut Microbiome Crowd: SCFA Receptors in T1D Pathology
por: Priyadarshini, Medha, et al.
Publicado: (2021)

Anti-Atherosclerotic Potential of Free Fatty Acid Receptor 4 (FFAR4)
por: Kiepura, Anna, et al.
Publicado: (2021)

Butyrate dictates ferroptosis sensitivity through FFAR2-mTOR signaling
por: Wang, GuoYan, et al.
Publicado: (2023)

The allosterically modulated FFAR2 is transactivated by signals generated by other neutrophil GPCRs
por: Lind, Simon, et al.
Publicado: (2023)

Hepatoprotective Effect of a New FFAR1 Agonist—N-Alkylated Isobornylamine
por: Pon`kina, Darya, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_klm2mq2i055djgnkf6q56k15ou