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IL-17A and TNF synergistically drive expression of proinflammatory mediators in synovial fibroblasts via IκBζ-dependent induction of ELF3

OBJECTIVE: IL-17A and TNF act in synergy to induce proinflammatory mediators in synovial fibroblasts thus contributing to diseases associated with chronic arthritis. Many of these factors are regulated by transcription factor E74-like factor-3 (ELF3). Therefore, we sought to investigate ELF3 as a do...

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Detalles Bibliográficos
Autores principales:	Kouri, Vesa-Petteri, Olkkonen, Juri, Nurmi, Katariina, Peled, Nitai, Ainola, Mari, Mandelin, Jami, Nordström, Dan C, Eklund, Kari K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Basic Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891425/ https://www.ncbi.nlm.nih.gov/pubmed/35792833 http://dx.doi.org/10.1093/rheumatology/keac385

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