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Effects of genetic polymorphisms on methotrexate levels and toxicity in Chinese patients with acute lymphoblastic leukemia

Methotrexate (MTX) has an antitumor effect when used for the treatment of acute lymphoblastic leukemia (ALL). This study aims at evaluating the associations between 14 polymorphisms of six genes involved in MTX metabolism with serum MTX concentration and toxicity accompanying high-dose MTX. Polymorp...

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Detalles Bibliográficos
Autores principales:	Hao, Qishan, Song, Yang, Fang, Qiuyun, Lin, Yani, Chen, Long, Wang, Xiaodan, Zhang, Ping, Wang, Zhe, Gong, Xiaoyuan, Liu, Kaiqi, Li, Qinghua, Tian, Zheng, Wang, Min, Wang, Jianxiang, Mi, Yingchang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891445/ https://www.ncbi.nlm.nih.gov/pubmed/36742186 http://dx.doi.org/10.1097/BS9.0000000000000142

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