Hematopoietic Cell Autonomous Disruption of Hematopoiesis in a Germline Loss-of-function Mouse Model of RUNX1-FPD

RUNX1 familial platelet disorder (RUNX1-FPD) is a hematopoietic disorder caused by germline loss-of-function mutations in the RUNX1 gene and characterized by thrombocytopathy, thrombocytopenia, and an increased risk of developing hematologic malignancies, mostly of myeloid origin. Disease pathophysi...

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Detalles Bibliográficos
Autores principales: Ernst, Martijn P. T., Pronk, Eline, van Dijk, Claire, van Strien, Paulina M. H., van Tienhoven, Tim V. D., Wevers, Michiel J. W., Sanders, Mathijs A., Bindels, Eric M. J., Speck, Nancy A., Raaijmakers, Marc H. G. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891454/
https://www.ncbi.nlm.nih.gov/pubmed/36741355
http://dx.doi.org/10.1097/HS9.0000000000000824

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