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Social isolation is linked to classical risk factors of Alzheimer’s disease-related dementias
Alzheimer’s disease and related dementias is a major public health burden–compounding over upcoming years due to longevity. Recently, clinical evidence hinted at the experience of social isolation in expediting dementia onset. In 502,506 UK Biobank participants and 30,097 participants from the Canad...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891507/ https://www.ncbi.nlm.nih.gov/pubmed/36724157 http://dx.doi.org/10.1371/journal.pone.0280471 |
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author | Shafighi, Kimia Villeneuve, Sylvia Rosa Neto, Pedro Badhwar, AmanPreet Poirier, Judes Sharma, Vaibhav Medina, Yasser Iturria Silveira, Patricia P. Dube, Laurette Glahn, David Bzdok, Danilo |
author_facet | Shafighi, Kimia Villeneuve, Sylvia Rosa Neto, Pedro Badhwar, AmanPreet Poirier, Judes Sharma, Vaibhav Medina, Yasser Iturria Silveira, Patricia P. Dube, Laurette Glahn, David Bzdok, Danilo |
author_sort | Shafighi, Kimia |
collection | PubMed |
description | Alzheimer’s disease and related dementias is a major public health burden–compounding over upcoming years due to longevity. Recently, clinical evidence hinted at the experience of social isolation in expediting dementia onset. In 502,506 UK Biobank participants and 30,097 participants from the Canadian Longitudinal Study of Aging, we revisited traditional risk factors for developing dementia in the context of loneliness and lacking social support. Across these measures of subjective and objective social deprivation, we have identified strong links between individuals’ social capital and various indicators of Alzheimer’s disease and related dementias risk, which replicated across both population cohorts. The quality and quantity of daily social encounters had deep connections with key aetiopathological factors, which represent 1) personal habits and lifestyle factors, 2) physical health, 3) mental health, and 4) societal and external factors. Our population-scale assessment suggest that social lifestyle determinants are linked to most neurodegeneration risk factors, highlighting them as promising targets for preventive clinical action. |
format | Online Article Text |
id | pubmed-9891507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-98915072023-02-02 Social isolation is linked to classical risk factors of Alzheimer’s disease-related dementias Shafighi, Kimia Villeneuve, Sylvia Rosa Neto, Pedro Badhwar, AmanPreet Poirier, Judes Sharma, Vaibhav Medina, Yasser Iturria Silveira, Patricia P. Dube, Laurette Glahn, David Bzdok, Danilo PLoS One Research Article Alzheimer’s disease and related dementias is a major public health burden–compounding over upcoming years due to longevity. Recently, clinical evidence hinted at the experience of social isolation in expediting dementia onset. In 502,506 UK Biobank participants and 30,097 participants from the Canadian Longitudinal Study of Aging, we revisited traditional risk factors for developing dementia in the context of loneliness and lacking social support. Across these measures of subjective and objective social deprivation, we have identified strong links between individuals’ social capital and various indicators of Alzheimer’s disease and related dementias risk, which replicated across both population cohorts. The quality and quantity of daily social encounters had deep connections with key aetiopathological factors, which represent 1) personal habits and lifestyle factors, 2) physical health, 3) mental health, and 4) societal and external factors. Our population-scale assessment suggest that social lifestyle determinants are linked to most neurodegeneration risk factors, highlighting them as promising targets for preventive clinical action. Public Library of Science 2023-02-01 /pmc/articles/PMC9891507/ /pubmed/36724157 http://dx.doi.org/10.1371/journal.pone.0280471 Text en © 2023 Shafighi et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Shafighi, Kimia Villeneuve, Sylvia Rosa Neto, Pedro Badhwar, AmanPreet Poirier, Judes Sharma, Vaibhav Medina, Yasser Iturria Silveira, Patricia P. Dube, Laurette Glahn, David Bzdok, Danilo Social isolation is linked to classical risk factors of Alzheimer’s disease-related dementias |
title | Social isolation is linked to classical risk factors of Alzheimer’s disease-related dementias |
title_full | Social isolation is linked to classical risk factors of Alzheimer’s disease-related dementias |
title_fullStr | Social isolation is linked to classical risk factors of Alzheimer’s disease-related dementias |
title_full_unstemmed | Social isolation is linked to classical risk factors of Alzheimer’s disease-related dementias |
title_short | Social isolation is linked to classical risk factors of Alzheimer’s disease-related dementias |
title_sort | social isolation is linked to classical risk factors of alzheimer’s disease-related dementias |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891507/ https://www.ncbi.nlm.nih.gov/pubmed/36724157 http://dx.doi.org/10.1371/journal.pone.0280471 |
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