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Apical fibrosis was the most common incidental pulmonary finding in a familial Mediterranean fever cohort
INTRODUCTION: Familial Mediterranean fever (FMF) is one of the common autoinflammatory diseases with multisystemic manifestation. Pleuritis is the only known pulmonary involvement of FMF; however, as far as we know, thoracic involvements in pleural, parenchymal, bronchial, and vascular structures ha...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891658/ https://www.ncbi.nlm.nih.gov/pubmed/36725780 http://dx.doi.org/10.1007/s10067-023-06526-7 |
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author | Şen, Nesrin Acer Kasman, Sevtap Baysal, Tamer Dizman, Rıdvan Yılmaz-Öner, Sibel Tezcan, Mehmet Engin |
author_facet | Şen, Nesrin Acer Kasman, Sevtap Baysal, Tamer Dizman, Rıdvan Yılmaz-Öner, Sibel Tezcan, Mehmet Engin |
author_sort | Şen, Nesrin |
collection | PubMed |
description | INTRODUCTION: Familial Mediterranean fever (FMF) is one of the common autoinflammatory diseases with multisystemic manifestation. Pleuritis is the only known pulmonary involvement of FMF; however, as far as we know, thoracic involvements in pleural, parenchymal, bronchial, and vascular structures have not been evaluated yet. METHOD: We included 243 consecutive FMF patients who applied to our clinic within the last 5 years and were requested to have a thorax CT for any reason and 122 trauma patients without any comorbidity. An experienced radiologist evaluated the thorax CT images blindly according to the relevant guidelines. We then presented the common incidental pulmonary and mediastinal findings on the thorax CT. Additionally, we compared patients with and without lung involvement according to demographic and disease-related parameters. RESULTS: In our study, 167 of 243 patients (68.7%) had at least one of the pulmonary findings on their thorax CT. The most common pulmonary findings were apical fibrosis in 96 (39.5%) patients, parenchymal fibrotic changes in 48 (19.8%) patients, and a solitary parenchymal nodule smaller than 4 mm in 33 (13.6%) patients. All demographic, genetic, and disease-related characteristics, including the frequency of spondyloarthropathy, were similar in patients with and without pulmonary findings. CONCLUSIONS: We showed that the most common incidental pulmonary finding in our FMF cohort was apical fibrosis on thoracic CT. Our data did not show causality between FMF and apical fibrosis; therefore, more studies are needed to evaluate the frequency and clinical significance of apical fibrosis in FMF. |
format | Online Article Text |
id | pubmed-9891658 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-98916582023-02-02 Apical fibrosis was the most common incidental pulmonary finding in a familial Mediterranean fever cohort Şen, Nesrin Acer Kasman, Sevtap Baysal, Tamer Dizman, Rıdvan Yılmaz-Öner, Sibel Tezcan, Mehmet Engin Clin Rheumatol Original Article INTRODUCTION: Familial Mediterranean fever (FMF) is one of the common autoinflammatory diseases with multisystemic manifestation. Pleuritis is the only known pulmonary involvement of FMF; however, as far as we know, thoracic involvements in pleural, parenchymal, bronchial, and vascular structures have not been evaluated yet. METHOD: We included 243 consecutive FMF patients who applied to our clinic within the last 5 years and were requested to have a thorax CT for any reason and 122 trauma patients without any comorbidity. An experienced radiologist evaluated the thorax CT images blindly according to the relevant guidelines. We then presented the common incidental pulmonary and mediastinal findings on the thorax CT. Additionally, we compared patients with and without lung involvement according to demographic and disease-related parameters. RESULTS: In our study, 167 of 243 patients (68.7%) had at least one of the pulmonary findings on their thorax CT. The most common pulmonary findings were apical fibrosis in 96 (39.5%) patients, parenchymal fibrotic changes in 48 (19.8%) patients, and a solitary parenchymal nodule smaller than 4 mm in 33 (13.6%) patients. All demographic, genetic, and disease-related characteristics, including the frequency of spondyloarthropathy, were similar in patients with and without pulmonary findings. CONCLUSIONS: We showed that the most common incidental pulmonary finding in our FMF cohort was apical fibrosis on thoracic CT. Our data did not show causality between FMF and apical fibrosis; therefore, more studies are needed to evaluate the frequency and clinical significance of apical fibrosis in FMF. Springer International Publishing 2023-02-01 2023 /pmc/articles/PMC9891658/ /pubmed/36725780 http://dx.doi.org/10.1007/s10067-023-06526-7 Text en © The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR) 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Article Şen, Nesrin Acer Kasman, Sevtap Baysal, Tamer Dizman, Rıdvan Yılmaz-Öner, Sibel Tezcan, Mehmet Engin Apical fibrosis was the most common incidental pulmonary finding in a familial Mediterranean fever cohort |
title | Apical fibrosis was the most common incidental pulmonary finding in a familial Mediterranean fever cohort |
title_full | Apical fibrosis was the most common incidental pulmonary finding in a familial Mediterranean fever cohort |
title_fullStr | Apical fibrosis was the most common incidental pulmonary finding in a familial Mediterranean fever cohort |
title_full_unstemmed | Apical fibrosis was the most common incidental pulmonary finding in a familial Mediterranean fever cohort |
title_short | Apical fibrosis was the most common incidental pulmonary finding in a familial Mediterranean fever cohort |
title_sort | apical fibrosis was the most common incidental pulmonary finding in a familial mediterranean fever cohort |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891658/ https://www.ncbi.nlm.nih.gov/pubmed/36725780 http://dx.doi.org/10.1007/s10067-023-06526-7 |
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