NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8

Enhancing the intracellular labile iron pool (LIP) represents a powerful, yet untapped strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron homeostasis by controlling HERC2 (E3 ubiquitin ligase for NCOA4 and FBXL5) and VAMP8 (mediates autophagosome-lysosome...

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Detalles Bibliográficos
Autores principales: Anandhan, Annadurai, Dodson, Matthew, Shakya, Aryatara, Chen, Jinjing, Liu, Pengfei, Wei, Yongyi, Tan, Hui, Wang, Qian, Jiang, Ziyan, Yang, Kevin, Garcia, Joe GN, Chambers, Setsuko K., Chapman, Eli, Ooi, Aikseng, Yang-Hartwich, Yang, Stockwell, Brent R., Zhang, Donna D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891695/
https://www.ncbi.nlm.nih.gov/pubmed/36724221
http://dx.doi.org/10.1126/sciadv.ade9585

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