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Big data mining, rational modification, and ancestral sequence reconstruction inferred multiple xylose isomerases for biorefinery

The isomerization of xylose to xylulose is considered the most promising approach to initiate xylose bioconversion. Here, phylogeny-guided big data mining, rational modification, and ancestral sequence reconstruction strategies were implemented to explore new active xylose isomerases (XIs) for Sacch...

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Detalles Bibliográficos
Autores principales: Chen, Sitong, Xu, Zhaoxian, Ding, Boning, Zhang, Yuwei, Liu, Shuangmei, Cai, Chenggu, Li, Muzi, Dale, Bruce E., Jin, Mingjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891696/
https://www.ncbi.nlm.nih.gov/pubmed/36724227
http://dx.doi.org/10.1126/sciadv.add8835