PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition

Phosphatidylinositol (PI)regulating enzymes are frequently altered in cancer and have become a focus for drug development. Here, we explore the phosphatidylinositol-5-phosphate 4-kinases (PI5P4K), a family of lipid kinases that regulate pools of intracellular PI, and demonstrate that the PI5P4Kα iso...

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Detalles Bibliográficos
Autores principales: Triscott, Joanna, Reist, Matthias, Küng, Lukas, Moselle, Francielle C., Lehner, Marika, Gallon, John, Ravi, Archna, Arora, Gurpreet K., de Brot, Simone, Lundquist, Mark, Gallart-Ayala, Hector, Ivanisevic, Julijana, Piscuoglio, Salvatore, Cantley, Lewis C., Emerling, Brooke M., Rubin, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891700/
https://www.ncbi.nlm.nih.gov/pubmed/36724278
http://dx.doi.org/10.1126/sciadv.ade8641

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