CEACAMS 1, 5, and 6 in disease and cancer: interactions with pathogens

The CEA family comprises 18 genes and 11 pseudogenes located at chromosome 19q13.2 and is divided into two main groups: cell surface anchored CEA-related cell adhesion molecules (CEACAMs) and the secreted pregnancy-specific glycoproteins (PSGs). CEACAMs are highly glycosylated cell surface anchored,...

Descripción completa

Detalles Bibliográficos
Autores principales: Thomas, Jerin, Klebanov, Addison, John, Sahara, Miller, Larry S., Vegesna, Anil, Amdur, Richard L., Bhowmick, Krishanu, Mishra, Lopa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891707/
https://www.ncbi.nlm.nih.gov/pubmed/36741860
http://dx.doi.org/10.18632/genesandcancer.230
_version_ 1784881189054578688
author Thomas, Jerin
Klebanov, Addison
John, Sahara
Miller, Larry S.
Vegesna, Anil
Amdur, Richard L.
Bhowmick, Krishanu
Mishra, Lopa
author_facet Thomas, Jerin
Klebanov, Addison
John, Sahara
Miller, Larry S.
Vegesna, Anil
Amdur, Richard L.
Bhowmick, Krishanu
Mishra, Lopa
author_sort Thomas, Jerin
collection PubMed
description The CEA family comprises 18 genes and 11 pseudogenes located at chromosome 19q13.2 and is divided into two main groups: cell surface anchored CEA-related cell adhesion molecules (CEACAMs) and the secreted pregnancy-specific glycoproteins (PSGs). CEACAMs are highly glycosylated cell surface anchored, intracellular, and intercellular signaling molecules with diverse functions, from cell differentiation and transformation to modulating immune responses associated with infection, inflammation, and cancer. In this review, we explore current knowledge surrounding CEACAM1, CEACAM5, and CEACAM6, highlight their pathological significance in the areas of cancer biology, immunology, and inflammatory disease, and describe the utility of murine models in exploring questions related to these proteins.
format Online
Article
Text
id pubmed-9891707
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-98917072023-02-02 CEACAMS 1, 5, and 6 in disease and cancer: interactions with pathogens Thomas, Jerin Klebanov, Addison John, Sahara Miller, Larry S. Vegesna, Anil Amdur, Richard L. Bhowmick, Krishanu Mishra, Lopa Genes Cancer Review The CEA family comprises 18 genes and 11 pseudogenes located at chromosome 19q13.2 and is divided into two main groups: cell surface anchored CEA-related cell adhesion molecules (CEACAMs) and the secreted pregnancy-specific glycoproteins (PSGs). CEACAMs are highly glycosylated cell surface anchored, intracellular, and intercellular signaling molecules with diverse functions, from cell differentiation and transformation to modulating immune responses associated with infection, inflammation, and cancer. In this review, we explore current knowledge surrounding CEACAM1, CEACAM5, and CEACAM6, highlight their pathological significance in the areas of cancer biology, immunology, and inflammatory disease, and describe the utility of murine models in exploring questions related to these proteins. Impact Journals LLC 2023-02-01 /pmc/articles/PMC9891707/ /pubmed/36741860 http://dx.doi.org/10.18632/genesandcancer.230 Text en https://creativecommons.org/licenses/by/3.0/Copyright: © 2023 Thomas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Thomas, Jerin
Klebanov, Addison
John, Sahara
Miller, Larry S.
Vegesna, Anil
Amdur, Richard L.
Bhowmick, Krishanu
Mishra, Lopa
CEACAMS 1, 5, and 6 in disease and cancer: interactions with pathogens
title CEACAMS 1, 5, and 6 in disease and cancer: interactions with pathogens
title_full CEACAMS 1, 5, and 6 in disease and cancer: interactions with pathogens
title_fullStr CEACAMS 1, 5, and 6 in disease and cancer: interactions with pathogens
title_full_unstemmed CEACAMS 1, 5, and 6 in disease and cancer: interactions with pathogens
title_short CEACAMS 1, 5, and 6 in disease and cancer: interactions with pathogens
title_sort ceacams 1, 5, and 6 in disease and cancer: interactions with pathogens
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891707/
https://www.ncbi.nlm.nih.gov/pubmed/36741860
http://dx.doi.org/10.18632/genesandcancer.230
work_keys_str_mv AT thomasjerin ceacams15and6indiseaseandcancerinteractionswithpathogens
AT klebanovaddison ceacams15and6indiseaseandcancerinteractionswithpathogens
AT johnsahara ceacams15and6indiseaseandcancerinteractionswithpathogens
AT millerlarrys ceacams15and6indiseaseandcancerinteractionswithpathogens
AT vegesnaanil ceacams15and6indiseaseandcancerinteractionswithpathogens
AT amdurrichardl ceacams15and6indiseaseandcancerinteractionswithpathogens
AT bhowmickkrishanu ceacams15and6indiseaseandcancerinteractionswithpathogens
AT mishralopa ceacams15and6indiseaseandcancerinteractionswithpathogens

Ejemplares similares