MCT1-dependent energetic failure and neuroinflammation underlie optic nerve degeneration in Wolfram syndrome mice

Wolfram syndrome 1 (WS1) is a rare genetic disorder caused by mutations in the WFS1 gene leading to a wide spectrum of clinical dysfunctions, among which blindness, diabetes, and neurological deficits are the most prominent. WFS1 encodes for the endoplasmic reticulum (ER) resident transmembrane prot...

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Detalles Bibliográficos
Autores principales: Rossi, Greta, Ordazzo, Gabriele, Vanni, Niccolò N, Castoldi, Valerio, Iannielli, Angelo, Di Silvestre, Dario, Bellini, Edoardo, Bernardo, Letizia, Giannelli, Serena G, Luoni, Mirko, Muggeo, Sharon, Leocani, Letizia, Mauri, PierLuigi, Broccoli, Vania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891717/
https://www.ncbi.nlm.nih.gov/pubmed/36645345
http://dx.doi.org/10.7554/eLife.81779

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