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α‐Synuclein aggregation causes muscle atrophy through neuromuscular junction degeneration

BACKGROUND: Sarcopenia is common in patients with Parkinson's disease (PD), showing mitochondrial oxidative stress in skeletal muscle. The aggregation of α‐synuclein (α‐Syn) to induce oxidative stress is a key pathogenic process of PD; nevertheless, we know little about its potential role in re...

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Detalles Bibliográficos
Autores principales: Yang, Qiumei, Wang, Yanyan, Zhao, Chunsong, Pang, Shimin, Lu, Jing, Chan, Piu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891985/
https://www.ncbi.nlm.nih.gov/pubmed/36416282
http://dx.doi.org/10.1002/jcsm.13123