Human T(H)17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation

It has been shown that innate immune responses can adopt adaptive properties such as memory. Whether T cells utilize innate immune signaling pathways to diversify their repertoire of effector functions is unknown. Gasdermin E (GSDME) is a membrane pore-forming molecule that has been shown to execute...

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Detalles Bibliográficos
Autores principales: Chao, Ying-Yin, Puhach, Alisa, Frieser, David, Arunkumar, Mahima, Lehner, Laurens, Seeholzer, Thomas, Garcia-Lopez, Albert, van der Wal, Marlot, Fibi-Smetana, Silvia, Dietschmann, Axel, Sommermann, Thomas, Ćiković, Tamara, Taher, Leila, Gresnigt, Mark S., Vastert, Sebastiaan J., van Wijk, Femke, Panagiotou, Gianni, Krappmann, Daniel, Groß, Olaf, Zielinski, Christina E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892007/
https://www.ncbi.nlm.nih.gov/pubmed/36604548
http://dx.doi.org/10.1038/s41590-022-01386-w

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