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MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma

Hypoxia is an important tumor feature and hypoxia-inducible factor 1 (HIF-1) is a master regulator of cell response to hypoxia. Mouse double minute 2 homolog (MDM2) promotes cancer cell survival in retinoblastoma (RB), with the underlying mechanism remaining elusive. In this study, we investigated t...

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Detalles Bibliográficos
Autores principales:	Zhang, Shouhua, Xu, Hongyan, Li, Weiming, Ji, Jianfeng, Jin, Qifang, Chen, Leifeng, Gan, Qiang, Tao, Qiang, Chai, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pathology and Oncology Archive
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892057/ https://www.ncbi.nlm.nih.gov/pubmed/36741966 http://dx.doi.org/10.3389/pore.2023.1610801

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