Cargando…

Filling the gap between the heart and the body in acromegaly: a case-control study

OBJECTIVE: Cardiovascul diseases are the most common comorbidities in acromegaly. Potential parameters in pathology of cardiovascular comorbidities are changes in levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) as well as body composition parameters. PURPOSE: The aim of this s...

Descripción completa

Detalles Bibliográficos
Autores principales: Ságová, Ivana, Dragula, Milan, Mokáň, Marián, Vaňuga, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892104/
https://www.ncbi.nlm.nih.gov/pubmed/36309947
http://dx.doi.org/10.1007/s12020-022-03232-3
_version_ 1784881279246794752
author Ságová, Ivana
Dragula, Milan
Mokáň, Marián
Vaňuga, Peter
author_facet Ságová, Ivana
Dragula, Milan
Mokáň, Marián
Vaňuga, Peter
author_sort Ságová, Ivana
collection PubMed
description OBJECTIVE: Cardiovascul diseases are the most common comorbidities in acromegaly. Potential parameters in pathology of cardiovascular comorbidities are changes in levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) as well as body composition parameters. PURPOSE: The aim of this study was to examine morphological and functional parameters of the cardiovascular system by echocardiography and to assess its relationship with disease activity and body composition parameters. METHODS: We prospectively enroled 129 acromegalic patients (82 females, 47 males) and 80 healthy controls (53 females, 27 males) matched for age, gender, and BMI. All patients underwent two-dimensional echocardiography. Body composition parameters were assessed by dual-energy X-ray absorptiometry. RESULTS: Acromegaly patients presented with higher left ventricle mass (LVM) compared to controls (LVMI: 123 ± 45 g/m(2) vs 83 ± 16 g/m(2), P < 0.001). Prevalence of left ventricle hypertrophy in acromegaly patients was 67% (78% concentric, 22% eccentric). IGF -1 levels, BMI, and lean mass positively correlated with LVM in all acromegaly patients (P < 0.001). Fat mass positively correlated with LVM in females (R = 0.306, P = 0.005), but this correlation was not found in males. We did not find any difference in size of the left and right ventricle between acromegaly patients and controls. Acromegaly patients presented with left atrium enlargement, diastolic dysfunction and low incidence of systolic dysfunction. Valvopathy was found in 43% of patients with predominant (31%) prevalence of mitral regurgitation. CONCLUSION: Our study demonstrates higher prevalence of cardiovascular comorbidities in acromegaly patients and the impact of IGF-1 levels and body composition parameters in pathology in some of these comorbidities.
format Online
Article
Text
id pubmed-9892104
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-98921042023-02-03 Filling the gap between the heart and the body in acromegaly: a case-control study Ságová, Ivana Dragula, Milan Mokáň, Marián Vaňuga, Peter Endocrine Original Article OBJECTIVE: Cardiovascul diseases are the most common comorbidities in acromegaly. Potential parameters in pathology of cardiovascular comorbidities are changes in levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) as well as body composition parameters. PURPOSE: The aim of this study was to examine morphological and functional parameters of the cardiovascular system by echocardiography and to assess its relationship with disease activity and body composition parameters. METHODS: We prospectively enroled 129 acromegalic patients (82 females, 47 males) and 80 healthy controls (53 females, 27 males) matched for age, gender, and BMI. All patients underwent two-dimensional echocardiography. Body composition parameters were assessed by dual-energy X-ray absorptiometry. RESULTS: Acromegaly patients presented with higher left ventricle mass (LVM) compared to controls (LVMI: 123 ± 45 g/m(2) vs 83 ± 16 g/m(2), P < 0.001). Prevalence of left ventricle hypertrophy in acromegaly patients was 67% (78% concentric, 22% eccentric). IGF -1 levels, BMI, and lean mass positively correlated with LVM in all acromegaly patients (P < 0.001). Fat mass positively correlated with LVM in females (R = 0.306, P = 0.005), but this correlation was not found in males. We did not find any difference in size of the left and right ventricle between acromegaly patients and controls. Acromegaly patients presented with left atrium enlargement, diastolic dysfunction and low incidence of systolic dysfunction. Valvopathy was found in 43% of patients with predominant (31%) prevalence of mitral regurgitation. CONCLUSION: Our study demonstrates higher prevalence of cardiovascular comorbidities in acromegaly patients and the impact of IGF-1 levels and body composition parameters in pathology in some of these comorbidities. Springer US 2022-10-30 2023 /pmc/articles/PMC9892104/ /pubmed/36309947 http://dx.doi.org/10.1007/s12020-022-03232-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Ságová, Ivana
Dragula, Milan
Mokáň, Marián
Vaňuga, Peter
Filling the gap between the heart and the body in acromegaly: a case-control study
title Filling the gap between the heart and the body in acromegaly: a case-control study
title_full Filling the gap between the heart and the body in acromegaly: a case-control study
title_fullStr Filling the gap between the heart and the body in acromegaly: a case-control study
title_full_unstemmed Filling the gap between the heart and the body in acromegaly: a case-control study
title_short Filling the gap between the heart and the body in acromegaly: a case-control study
title_sort filling the gap between the heart and the body in acromegaly: a case-control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892104/
https://www.ncbi.nlm.nih.gov/pubmed/36309947
http://dx.doi.org/10.1007/s12020-022-03232-3
work_keys_str_mv AT sagovaivana fillingthegapbetweentheheartandthebodyinacromegalyacasecontrolstudy
AT dragulamilan fillingthegapbetweentheheartandthebodyinacromegalyacasecontrolstudy
AT mokanmarian fillingthegapbetweentheheartandthebodyinacromegalyacasecontrolstudy
AT vanugapeter fillingthegapbetweentheheartandthebodyinacromegalyacasecontrolstudy