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Successful Liver Transplantation After Neurologically Determined Death Donation Following Sodium Nitrite Poisoning

Sodium nitrite poisoning has been reported with increasing frequency since 2017 and popularized on social media as an effective means to commit suicide. Though accidental, non-intentional consumption has been reported, it is uncommon. Sodium nitrite is a colorless, odorless, yellowish-white crystall...

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Autores principales: Mathuram Thiyagarajan, Umasankar, James Shapiro, A M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892231/
https://www.ncbi.nlm.nih.gov/pubmed/36741606
http://dx.doi.org/10.7759/cureus.33278
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author Mathuram Thiyagarajan, Umasankar
James Shapiro, A M
author_facet Mathuram Thiyagarajan, Umasankar
James Shapiro, A M
author_sort Mathuram Thiyagarajan, Umasankar
collection PubMed
description Sodium nitrite poisoning has been reported with increasing frequency since 2017 and popularized on social media as an effective means to commit suicide. Though accidental, non-intentional consumption has been reported, it is uncommon. Sodium nitrite is a colorless, odorless, yellowish-white crystalline material that resembles table salt, is easily ingested for self-harm, and is readily accessible through purchase from online portals at low cost. The chemical is used industrially as a curing agent for meat, fish, and cheese, as it inhibits Clostridium botulinum and prevents botulism. We herein report a successful case of liver transplantation from an organ donor who suffered brain death after intentional sodium nitrite consumption. Despite conflicting evidence on sodium nitrite's toxic versus protective effects on the liver, our transplant recipient showed normal graft function in the four months following liver transplantation. It would have been helpful and reassuring to have had access to similar positive case reports when deciding to use such a donor.
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spelling pubmed-98922312023-02-02 Successful Liver Transplantation After Neurologically Determined Death Donation Following Sodium Nitrite Poisoning Mathuram Thiyagarajan, Umasankar James Shapiro, A M Cureus Emergency Medicine Sodium nitrite poisoning has been reported with increasing frequency since 2017 and popularized on social media as an effective means to commit suicide. Though accidental, non-intentional consumption has been reported, it is uncommon. Sodium nitrite is a colorless, odorless, yellowish-white crystalline material that resembles table salt, is easily ingested for self-harm, and is readily accessible through purchase from online portals at low cost. The chemical is used industrially as a curing agent for meat, fish, and cheese, as it inhibits Clostridium botulinum and prevents botulism. We herein report a successful case of liver transplantation from an organ donor who suffered brain death after intentional sodium nitrite consumption. Despite conflicting evidence on sodium nitrite's toxic versus protective effects on the liver, our transplant recipient showed normal graft function in the four months following liver transplantation. It would have been helpful and reassuring to have had access to similar positive case reports when deciding to use such a donor. Cureus 2023-01-02 /pmc/articles/PMC9892231/ /pubmed/36741606 http://dx.doi.org/10.7759/cureus.33278 Text en Copyright © 2023, Mathuram Thiyagarajan et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Emergency Medicine
Mathuram Thiyagarajan, Umasankar
James Shapiro, A M
Successful Liver Transplantation After Neurologically Determined Death Donation Following Sodium Nitrite Poisoning
title Successful Liver Transplantation After Neurologically Determined Death Donation Following Sodium Nitrite Poisoning
title_full Successful Liver Transplantation After Neurologically Determined Death Donation Following Sodium Nitrite Poisoning
title_fullStr Successful Liver Transplantation After Neurologically Determined Death Donation Following Sodium Nitrite Poisoning
title_full_unstemmed Successful Liver Transplantation After Neurologically Determined Death Donation Following Sodium Nitrite Poisoning
title_short Successful Liver Transplantation After Neurologically Determined Death Donation Following Sodium Nitrite Poisoning
title_sort successful liver transplantation after neurologically determined death donation following sodium nitrite poisoning
topic Emergency Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892231/
https://www.ncbi.nlm.nih.gov/pubmed/36741606
http://dx.doi.org/10.7759/cureus.33278
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