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Increased Incidence and Severity of New Graves Disease Diagnoses in Youth During the COVID-19 Pandemic
OBJECTIVE: Graves disease (GD), an autoimmune disease of the thyroid, is likely caused by a combination of genetic predisposition and environmental triggers. Recent data suggest that COVID-19 may be associated with the development of autoimmune disease. The aim of this study was to assess the incide...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AACE. Published by Elsevier Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892249/ https://www.ncbi.nlm.nih.gov/pubmed/36736538 http://dx.doi.org/10.1016/j.eprac.2023.01.011 |
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author | Donner, Julia R. Has, Phinnara Topor, Lisa Swartz |
author_facet | Donner, Julia R. Has, Phinnara Topor, Lisa Swartz |
author_sort | Donner, Julia R. |
collection | PubMed |
description | OBJECTIVE: Graves disease (GD), an autoimmune disease of the thyroid, is likely caused by a combination of genetic predisposition and environmental triggers. Recent data suggest that COVID-19 may be associated with the development of autoimmune disease. The aim of this study was to assess the incidence and characteristics of new GD diagnoses in youth prior to and during the COVID-19 pandemic. METHODS: We performed a retrospective chart review of all new GD diagnoses in patients aged 0 to 18 years diagnosed at a tertiary care pediatric hospital between January 1, 2018, and December 31, 2021. RESULTS: Over a 4-year period, 51 patients had been diagnosed with new-onset GD. We observed an increased incidence in new-onset GD during the pandemic compared with that in the 2 prior years (P = .01). During the pandemic period, heart rates (P = .03) as well as systolic (P = .005) and diastolic (P = .01) blood pressures were higher at initial evaluation, patients more frequently reported palpitations (P = .03) and tremors (P = .04), and an increased proportion of patients required beta-blockade treatment at diagnosis (P = .002). The percentage of patients requiring thionamide treatment and thionamide doses had been similar over time. CONCLUSION: We identified an increase in new-onset pediatric GD diagnoses during the COVID-19 pandemic. In addition, youths had increased severity of symptoms and more frequently required beta-blockade treatment at diagnosis. Further study of the relationship between COVID-19 and autoimmune thyroid disease is needed. |
format | Online Article Text |
id | pubmed-9892249 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | AACE. Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98922492023-02-02 Increased Incidence and Severity of New Graves Disease Diagnoses in Youth During the COVID-19 Pandemic Donner, Julia R. Has, Phinnara Topor, Lisa Swartz Endocr Pract Original Article OBJECTIVE: Graves disease (GD), an autoimmune disease of the thyroid, is likely caused by a combination of genetic predisposition and environmental triggers. Recent data suggest that COVID-19 may be associated with the development of autoimmune disease. The aim of this study was to assess the incidence and characteristics of new GD diagnoses in youth prior to and during the COVID-19 pandemic. METHODS: We performed a retrospective chart review of all new GD diagnoses in patients aged 0 to 18 years diagnosed at a tertiary care pediatric hospital between January 1, 2018, and December 31, 2021. RESULTS: Over a 4-year period, 51 patients had been diagnosed with new-onset GD. We observed an increased incidence in new-onset GD during the pandemic compared with that in the 2 prior years (P = .01). During the pandemic period, heart rates (P = .03) as well as systolic (P = .005) and diastolic (P = .01) blood pressures were higher at initial evaluation, patients more frequently reported palpitations (P = .03) and tremors (P = .04), and an increased proportion of patients required beta-blockade treatment at diagnosis (P = .002). The percentage of patients requiring thionamide treatment and thionamide doses had been similar over time. CONCLUSION: We identified an increase in new-onset pediatric GD diagnoses during the COVID-19 pandemic. In addition, youths had increased severity of symptoms and more frequently required beta-blockade treatment at diagnosis. Further study of the relationship between COVID-19 and autoimmune thyroid disease is needed. AACE. Published by Elsevier Inc. 2023-05 2023-02-02 /pmc/articles/PMC9892249/ /pubmed/36736538 http://dx.doi.org/10.1016/j.eprac.2023.01.011 Text en © 2023 AACE. Published by Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Article Donner, Julia R. Has, Phinnara Topor, Lisa Swartz Increased Incidence and Severity of New Graves Disease Diagnoses in Youth During the COVID-19 Pandemic |
title | Increased Incidence and Severity of New Graves Disease Diagnoses in Youth During the COVID-19 Pandemic |
title_full | Increased Incidence and Severity of New Graves Disease Diagnoses in Youth During the COVID-19 Pandemic |
title_fullStr | Increased Incidence and Severity of New Graves Disease Diagnoses in Youth During the COVID-19 Pandemic |
title_full_unstemmed | Increased Incidence and Severity of New Graves Disease Diagnoses in Youth During the COVID-19 Pandemic |
title_short | Increased Incidence and Severity of New Graves Disease Diagnoses in Youth During the COVID-19 Pandemic |
title_sort | increased incidence and severity of new graves disease diagnoses in youth during the covid-19 pandemic |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892249/ https://www.ncbi.nlm.nih.gov/pubmed/36736538 http://dx.doi.org/10.1016/j.eprac.2023.01.011 |
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