Angiotensin Converting Enzyme 2 - at the Heart of the COVID-19 pandemic

ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the COVID-19 pandemic, it has become one of the most therapeutically-targeted human molecules in biomedicine. ACE2 serves two fundamental physiological roles: as an enzyme, it alters peptide cascade balance, and as a ch...

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Autores principales: Oudit, Gavin Y., Wang, Kaiming, Viveiros, Anissa, Kellner, Max J., Penninger, Josef M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892333/
https://www.ncbi.nlm.nih.gov/pubmed/36787743
http://dx.doi.org/10.1016/j.cell.2023.01.039
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author Oudit, Gavin Y.
Wang, Kaiming
Viveiros, Anissa
Kellner, Max J.
Penninger, Josef M.
author_facet Oudit, Gavin Y.
Wang, Kaiming
Viveiros, Anissa
Kellner, Max J.
Penninger, Josef M.
author_sort Oudit, Gavin Y.
collection PubMed
description ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the COVID-19 pandemic, it has become one of the most therapeutically-targeted human molecules in biomedicine. ACE2 serves two fundamental physiological roles: as an enzyme, it alters peptide cascade balance, and as a chaperone, it controls intestinal amino acid uptake. ACE2’s tissue distribution, affected by comorbidities and sex, explains the broad tropism of coronaviruses and the clinical manifestations of SARS and COVID-19. ACE2-based therapeutics provide a universal strategy to prevent and treat SARS-CoV-2 infections, applicable to all SARS-CoV-2 variants and other emerging zoonotic coronaviruses exploiting ACE2 as their cellular receptor.
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spelling pubmed-98923332023-02-02 Angiotensin Converting Enzyme 2 - at the Heart of the COVID-19 pandemic Oudit, Gavin Y. Wang, Kaiming Viveiros, Anissa Kellner, Max J. Penninger, Josef M. Cell Review ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the COVID-19 pandemic, it has become one of the most therapeutically-targeted human molecules in biomedicine. ACE2 serves two fundamental physiological roles: as an enzyme, it alters peptide cascade balance, and as a chaperone, it controls intestinal amino acid uptake. ACE2’s tissue distribution, affected by comorbidities and sex, explains the broad tropism of coronaviruses and the clinical manifestations of SARS and COVID-19. ACE2-based therapeutics provide a universal strategy to prevent and treat SARS-CoV-2 infections, applicable to all SARS-CoV-2 variants and other emerging zoonotic coronaviruses exploiting ACE2 as their cellular receptor. Elsevier Inc. 2023-02-02 /pmc/articles/PMC9892333/ /pubmed/36787743 http://dx.doi.org/10.1016/j.cell.2023.01.039 Text en © 2023 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Oudit, Gavin Y.
Wang, Kaiming
Viveiros, Anissa
Kellner, Max J.
Penninger, Josef M.
Angiotensin Converting Enzyme 2 - at the Heart of the COVID-19 pandemic
title Angiotensin Converting Enzyme 2 - at the Heart of the COVID-19 pandemic
title_full Angiotensin Converting Enzyme 2 - at the Heart of the COVID-19 pandemic
title_fullStr Angiotensin Converting Enzyme 2 - at the Heart of the COVID-19 pandemic
title_full_unstemmed Angiotensin Converting Enzyme 2 - at the Heart of the COVID-19 pandemic
title_short Angiotensin Converting Enzyme 2 - at the Heart of the COVID-19 pandemic
title_sort angiotensin converting enzyme 2 - at the heart of the covid-19 pandemic
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892333/
https://www.ncbi.nlm.nih.gov/pubmed/36787743
http://dx.doi.org/10.1016/j.cell.2023.01.039
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