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Radiation‐induced morphea of the breast—A case series

Radiation‐induced morphea (RIM) is a rare but recognized late complication of radiotherapy. It was first described in 1905, not long after the initial discovery of X‐rays by Roentgen. Characterized by the deposition of excess collagen in the dermis, it results in thickening of the skin. Its frequenc...

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Autores principales: Finnegan, Paula, Kiely, Lisa, Gallagher, Catriona, Mhaolcatha, Sarah Ni, Feeley, Linda, Fitzgibbon, Jim, White, Jessica, Bourke, John, Murphy, Lesley Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892419/
https://www.ncbi.nlm.nih.gov/pubmed/36751336
http://dx.doi.org/10.1002/ski2.148
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author Finnegan, Paula
Kiely, Lisa
Gallagher, Catriona
Mhaolcatha, Sarah Ni
Feeley, Linda
Fitzgibbon, Jim
White, Jessica
Bourke, John
Murphy, Lesley Ann
author_facet Finnegan, Paula
Kiely, Lisa
Gallagher, Catriona
Mhaolcatha, Sarah Ni
Feeley, Linda
Fitzgibbon, Jim
White, Jessica
Bourke, John
Murphy, Lesley Ann
author_sort Finnegan, Paula
collection PubMed
description Radiation‐induced morphea (RIM) is a rare but recognized late complication of radiotherapy. It was first described in 1905, not long after the initial discovery of X‐rays by Roentgen. Characterized by the deposition of excess collagen in the dermis, it results in thickening of the skin. Its frequency is approximately 2 in 1000. We present a series of three cases involving patients receiving radiotherapy treatment for breast cancer, each of which subsequently developed RIM. Because of its rarity, RIM is often misdiagnosed as infection or metastatic disease. This can lead to delayed diagnosis and treatment, leading to poorer outcomes such as chronic pain issues. Early dermatological involvement and tissue sampling to examine histopathological features can avoid this, leading to better care and improved results. A variety of treatment options are available, ranging from topical to systemic, with early induction more likely to result in a positive response.
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spelling pubmed-98924192023-02-06 Radiation‐induced morphea of the breast—A case series Finnegan, Paula Kiely, Lisa Gallagher, Catriona Mhaolcatha, Sarah Ni Feeley, Linda Fitzgibbon, Jim White, Jessica Bourke, John Murphy, Lesley Ann Skin Health Dis Case Reports Radiation‐induced morphea (RIM) is a rare but recognized late complication of radiotherapy. It was first described in 1905, not long after the initial discovery of X‐rays by Roentgen. Characterized by the deposition of excess collagen in the dermis, it results in thickening of the skin. Its frequency is approximately 2 in 1000. We present a series of three cases involving patients receiving radiotherapy treatment for breast cancer, each of which subsequently developed RIM. Because of its rarity, RIM is often misdiagnosed as infection or metastatic disease. This can lead to delayed diagnosis and treatment, leading to poorer outcomes such as chronic pain issues. Early dermatological involvement and tissue sampling to examine histopathological features can avoid this, leading to better care and improved results. A variety of treatment options are available, ranging from topical to systemic, with early induction more likely to result in a positive response. John Wiley and Sons Inc. 2022-06-29 /pmc/articles/PMC9892419/ /pubmed/36751336 http://dx.doi.org/10.1002/ski2.148 Text en © 2022 The Authors. Skin Health and Disease published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Finnegan, Paula
Kiely, Lisa
Gallagher, Catriona
Mhaolcatha, Sarah Ni
Feeley, Linda
Fitzgibbon, Jim
White, Jessica
Bourke, John
Murphy, Lesley Ann
Radiation‐induced morphea of the breast—A case series
title Radiation‐induced morphea of the breast—A case series
title_full Radiation‐induced morphea of the breast—A case series
title_fullStr Radiation‐induced morphea of the breast—A case series
title_full_unstemmed Radiation‐induced morphea of the breast—A case series
title_short Radiation‐induced morphea of the breast—A case series
title_sort radiation‐induced morphea of the breast—a case series
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892419/
https://www.ncbi.nlm.nih.gov/pubmed/36751336
http://dx.doi.org/10.1002/ski2.148
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