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Radiation‐induced morphea of the breast—A case series
Radiation‐induced morphea (RIM) is a rare but recognized late complication of radiotherapy. It was first described in 1905, not long after the initial discovery of X‐rays by Roentgen. Characterized by the deposition of excess collagen in the dermis, it results in thickening of the skin. Its frequenc...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892419/ https://www.ncbi.nlm.nih.gov/pubmed/36751336 http://dx.doi.org/10.1002/ski2.148 |
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author | Finnegan, Paula Kiely, Lisa Gallagher, Catriona Mhaolcatha, Sarah Ni Feeley, Linda Fitzgibbon, Jim White, Jessica Bourke, John Murphy, Lesley Ann |
author_facet | Finnegan, Paula Kiely, Lisa Gallagher, Catriona Mhaolcatha, Sarah Ni Feeley, Linda Fitzgibbon, Jim White, Jessica Bourke, John Murphy, Lesley Ann |
author_sort | Finnegan, Paula |
collection | PubMed |
description | Radiation‐induced morphea (RIM) is a rare but recognized late complication of radiotherapy. It was first described in 1905, not long after the initial discovery of X‐rays by Roentgen. Characterized by the deposition of excess collagen in the dermis, it results in thickening of the skin. Its frequency is approximately 2 in 1000. We present a series of three cases involving patients receiving radiotherapy treatment for breast cancer, each of which subsequently developed RIM. Because of its rarity, RIM is often misdiagnosed as infection or metastatic disease. This can lead to delayed diagnosis and treatment, leading to poorer outcomes such as chronic pain issues. Early dermatological involvement and tissue sampling to examine histopathological features can avoid this, leading to better care and improved results. A variety of treatment options are available, ranging from topical to systemic, with early induction more likely to result in a positive response. |
format | Online Article Text |
id | pubmed-9892419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98924192023-02-06 Radiation‐induced morphea of the breast—A case series Finnegan, Paula Kiely, Lisa Gallagher, Catriona Mhaolcatha, Sarah Ni Feeley, Linda Fitzgibbon, Jim White, Jessica Bourke, John Murphy, Lesley Ann Skin Health Dis Case Reports Radiation‐induced morphea (RIM) is a rare but recognized late complication of radiotherapy. It was first described in 1905, not long after the initial discovery of X‐rays by Roentgen. Characterized by the deposition of excess collagen in the dermis, it results in thickening of the skin. Its frequency is approximately 2 in 1000. We present a series of three cases involving patients receiving radiotherapy treatment for breast cancer, each of which subsequently developed RIM. Because of its rarity, RIM is often misdiagnosed as infection or metastatic disease. This can lead to delayed diagnosis and treatment, leading to poorer outcomes such as chronic pain issues. Early dermatological involvement and tissue sampling to examine histopathological features can avoid this, leading to better care and improved results. A variety of treatment options are available, ranging from topical to systemic, with early induction more likely to result in a positive response. John Wiley and Sons Inc. 2022-06-29 /pmc/articles/PMC9892419/ /pubmed/36751336 http://dx.doi.org/10.1002/ski2.148 Text en © 2022 The Authors. Skin Health and Disease published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Reports Finnegan, Paula Kiely, Lisa Gallagher, Catriona Mhaolcatha, Sarah Ni Feeley, Linda Fitzgibbon, Jim White, Jessica Bourke, John Murphy, Lesley Ann Radiation‐induced morphea of the breast—A case series |
title | Radiation‐induced morphea of the breast—A case series |
title_full | Radiation‐induced morphea of the breast—A case series |
title_fullStr | Radiation‐induced morphea of the breast—A case series |
title_full_unstemmed | Radiation‐induced morphea of the breast—A case series |
title_short | Radiation‐induced morphea of the breast—A case series |
title_sort | radiation‐induced morphea of the breast—a case series |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892419/ https://www.ncbi.nlm.nih.gov/pubmed/36751336 http://dx.doi.org/10.1002/ski2.148 |
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