Identifying CDC7 as a synergistic target of chemotherapy in resistant small-cell lung cancer via CRISPR/Cas9 screening

There is currently a lack of efficacious treatments for patients with chemo-resistant small-cell lung cancer (SCLC), leading to poor prognoses. We examined a chemo-resistant SCLC cell line using genome-wide CRISPR/Cas9 screening and identified serine/threonine kinase cell division cycle 7 (CDC7) as...

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Detalles Bibliográficos
Autores principales: Deng, Ling, Yang, Li, Zhu, Shuhan, Li, Man, Wang, Yu, Cao, Xiaolong, Wang, Qiongyao, Guo, Linlang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892530/
https://www.ncbi.nlm.nih.gov/pubmed/36725843
http://dx.doi.org/10.1038/s41420-023-01315-2

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