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Role of transcription factors in apoptotic cells clearance
The human body generates 10–100 billion cells every day, and the same number of cells die to maintain homeostasis. The genetically controlled, autonomously ordered cell death mainly proceeds by apoptosis. Apoptosis is an important way of programmed cell death in multicellular organisms, timely and e...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892555/ https://www.ncbi.nlm.nih.gov/pubmed/36743409 http://dx.doi.org/10.3389/fcell.2023.1110225 |
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author | Gao, Yuqiong Jiao, Yating Gong, Xiaoyi Liu, Jie Xiao, Hui Zheng, Qian |
author_facet | Gao, Yuqiong Jiao, Yating Gong, Xiaoyi Liu, Jie Xiao, Hui Zheng, Qian |
author_sort | Gao, Yuqiong |
collection | PubMed |
description | The human body generates 10–100 billion cells every day, and the same number of cells die to maintain homeostasis. The genetically controlled, autonomously ordered cell death mainly proceeds by apoptosis. Apoptosis is an important way of programmed cell death in multicellular organisms, timely and effective elimination of apoptotic cells plays a key role in the growth and development of organisms and the maintenance of homeostasis. During the clearance of apoptotic cells, transcription factors bind to specific target promoters and act as activators or repressors to regulate multiple genes expression, how transcription factors regulate apoptosis is an important and poorly understood aspect of normal development. This paper summarizes the regulatory mechanisms of transcription factors in the clearance of apoptotic cells to date. |
format | Online Article Text |
id | pubmed-9892555 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98925552023-02-03 Role of transcription factors in apoptotic cells clearance Gao, Yuqiong Jiao, Yating Gong, Xiaoyi Liu, Jie Xiao, Hui Zheng, Qian Front Cell Dev Biol Cell and Developmental Biology The human body generates 10–100 billion cells every day, and the same number of cells die to maintain homeostasis. The genetically controlled, autonomously ordered cell death mainly proceeds by apoptosis. Apoptosis is an important way of programmed cell death in multicellular organisms, timely and effective elimination of apoptotic cells plays a key role in the growth and development of organisms and the maintenance of homeostasis. During the clearance of apoptotic cells, transcription factors bind to specific target promoters and act as activators or repressors to regulate multiple genes expression, how transcription factors regulate apoptosis is an important and poorly understood aspect of normal development. This paper summarizes the regulatory mechanisms of transcription factors in the clearance of apoptotic cells to date. Frontiers Media S.A. 2023-01-19 /pmc/articles/PMC9892555/ /pubmed/36743409 http://dx.doi.org/10.3389/fcell.2023.1110225 Text en Copyright © 2023 Gao, Jiao, Gong, Liu, Xiao and Zheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Gao, Yuqiong Jiao, Yating Gong, Xiaoyi Liu, Jie Xiao, Hui Zheng, Qian Role of transcription factors in apoptotic cells clearance |
title | Role of transcription factors in apoptotic cells clearance |
title_full | Role of transcription factors in apoptotic cells clearance |
title_fullStr | Role of transcription factors in apoptotic cells clearance |
title_full_unstemmed | Role of transcription factors in apoptotic cells clearance |
title_short | Role of transcription factors in apoptotic cells clearance |
title_sort | role of transcription factors in apoptotic cells clearance |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892555/ https://www.ncbi.nlm.nih.gov/pubmed/36743409 http://dx.doi.org/10.3389/fcell.2023.1110225 |
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