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NHANES cross sectional study of aspirin and fractures in the elderly

Bone fractures are a global public health concern, yet no thorough investigation of low-dose aspirin usage to prevent fractures in the elderly has been conducted. Many interventional human and animal studies have tried to detect the correct role of low-dose aspirin on fractures in elderly persons. T...

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Autores principales: Swed, Sarya, El-Sakka, Amro A., Abouainain, Yasmeen, Lee, Ka Yiu, Sawaf, Bisher, Albuni, Mhd Kutaiba, Battikh, Elias, Ahmad, Eman Mohammed sharif, Elkalagi, Nashaat Kamal Hamdy, Abbas, Kirellos Said, Hafez, Wael, Rakab, Amine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892582/
https://www.ncbi.nlm.nih.gov/pubmed/36725971
http://dx.doi.org/10.1038/s41598-023-29029-6
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author Swed, Sarya
El-Sakka, Amro A.
Abouainain, Yasmeen
Lee, Ka Yiu
Sawaf, Bisher
Albuni, Mhd Kutaiba
Battikh, Elias
Ahmad, Eman Mohammed sharif
Elkalagi, Nashaat Kamal Hamdy
Abbas, Kirellos Said
Hafez, Wael
Rakab, Amine
author_facet Swed, Sarya
El-Sakka, Amro A.
Abouainain, Yasmeen
Lee, Ka Yiu
Sawaf, Bisher
Albuni, Mhd Kutaiba
Battikh, Elias
Ahmad, Eman Mohammed sharif
Elkalagi, Nashaat Kamal Hamdy
Abbas, Kirellos Said
Hafez, Wael
Rakab, Amine
author_sort Swed, Sarya
collection PubMed
description Bone fractures are a global public health concern, yet no thorough investigation of low-dose aspirin usage to prevent fractures in the elderly has been conducted. Many interventional human and animal studies have tried to detect the correct role of low-dose aspirin on fractures in elderly persons. The literature doesn't consist of a retrospective observational study that includes a large number of older individuals and evaluates the accurate effect of aspirin on the fractures post falling from low heights. This cross-sectional includes 7132 elderly persons and aimed to detect if there was a link between taking low-dose aspirin to prevent fractures in the elderly. Data was extracted from the National Health and Nutrition Examination Survey (NHANES) database for 2017–2020 and 2013–2014. Demographic and examination data were collected during in-home interviews and study visits to a mobile examination center. Standardized questionnaires were used to collect information such as age, gender, race, educational level, and family income-to-poverty ratio. Body mass index (BMI), weight, standing height, upper leg length, upper arm length, arm circumference, and wrist circumference were all measured during the examination. The study examined 8127 patients, with 7132 elderly patients suitable for data analysis. The odds ratio of fractures due to a fall from standing height or less was 0.963 (95 percent confidence interval 0.08–1.149) in low-dose aspirin users, while having parents with osteoporosis had a related risk of 1.23. (95 percent confidence interval 0.81–1.8). The total number of fractures was 1295; with hip fractures constituting up to 13.82%, wrist fractures of 66.56%, and spine fractures of 19.61%. There was no significant difference in femur and spine bone mineral density (BMD) in the two groups (use low dose aspirin and don't use). Females had a 5.6 times greater fracture risk related to a fall from standing height or less (1 time or more) than males (P-value < 0.001). Furthermore, taking aspirin had no effect on the occurrence of fractures from standing height or less in older people (P-value = 0.468). In addition, the logistic regression after performing the propensity matching score confirmed that there was no impact of taking aspirin on the occurrence of fractures (P-value > 0.05). This cross-sectional study reveals that taking low-dose aspirin to prevent fractures in the elderly is statistically insignificant. However, fractures are more common in older persons, especially in older women; thus, more widespread injury prevention initiatives and access to osteoporosis prevention and diagnosis for older people should improve to minimize the overall burden.
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spelling pubmed-98925822023-02-03 NHANES cross sectional study of aspirin and fractures in the elderly Swed, Sarya El-Sakka, Amro A. Abouainain, Yasmeen Lee, Ka Yiu Sawaf, Bisher Albuni, Mhd Kutaiba Battikh, Elias Ahmad, Eman Mohammed sharif Elkalagi, Nashaat Kamal Hamdy Abbas, Kirellos Said Hafez, Wael Rakab, Amine Sci Rep Article Bone fractures are a global public health concern, yet no thorough investigation of low-dose aspirin usage to prevent fractures in the elderly has been conducted. Many interventional human and animal studies have tried to detect the correct role of low-dose aspirin on fractures in elderly persons. The literature doesn't consist of a retrospective observational study that includes a large number of older individuals and evaluates the accurate effect of aspirin on the fractures post falling from low heights. This cross-sectional includes 7132 elderly persons and aimed to detect if there was a link between taking low-dose aspirin to prevent fractures in the elderly. Data was extracted from the National Health and Nutrition Examination Survey (NHANES) database for 2017–2020 and 2013–2014. Demographic and examination data were collected during in-home interviews and study visits to a mobile examination center. Standardized questionnaires were used to collect information such as age, gender, race, educational level, and family income-to-poverty ratio. Body mass index (BMI), weight, standing height, upper leg length, upper arm length, arm circumference, and wrist circumference were all measured during the examination. The study examined 8127 patients, with 7132 elderly patients suitable for data analysis. The odds ratio of fractures due to a fall from standing height or less was 0.963 (95 percent confidence interval 0.08–1.149) in low-dose aspirin users, while having parents with osteoporosis had a related risk of 1.23. (95 percent confidence interval 0.81–1.8). The total number of fractures was 1295; with hip fractures constituting up to 13.82%, wrist fractures of 66.56%, and spine fractures of 19.61%. There was no significant difference in femur and spine bone mineral density (BMD) in the two groups (use low dose aspirin and don't use). Females had a 5.6 times greater fracture risk related to a fall from standing height or less (1 time or more) than males (P-value < 0.001). Furthermore, taking aspirin had no effect on the occurrence of fractures from standing height or less in older people (P-value = 0.468). In addition, the logistic regression after performing the propensity matching score confirmed that there was no impact of taking aspirin on the occurrence of fractures (P-value > 0.05). This cross-sectional study reveals that taking low-dose aspirin to prevent fractures in the elderly is statistically insignificant. However, fractures are more common in older persons, especially in older women; thus, more widespread injury prevention initiatives and access to osteoporosis prevention and diagnosis for older people should improve to minimize the overall burden. Nature Publishing Group UK 2023-02-01 /pmc/articles/PMC9892582/ /pubmed/36725971 http://dx.doi.org/10.1038/s41598-023-29029-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Swed, Sarya
El-Sakka, Amro A.
Abouainain, Yasmeen
Lee, Ka Yiu
Sawaf, Bisher
Albuni, Mhd Kutaiba
Battikh, Elias
Ahmad, Eman Mohammed sharif
Elkalagi, Nashaat Kamal Hamdy
Abbas, Kirellos Said
Hafez, Wael
Rakab, Amine
NHANES cross sectional study of aspirin and fractures in the elderly
title NHANES cross sectional study of aspirin and fractures in the elderly
title_full NHANES cross sectional study of aspirin and fractures in the elderly
title_fullStr NHANES cross sectional study of aspirin and fractures in the elderly
title_full_unstemmed NHANES cross sectional study of aspirin and fractures in the elderly
title_short NHANES cross sectional study of aspirin and fractures in the elderly
title_sort nhanes cross sectional study of aspirin and fractures in the elderly
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892582/
https://www.ncbi.nlm.nih.gov/pubmed/36725971
http://dx.doi.org/10.1038/s41598-023-29029-6
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