Segregation of D1 and D2 dopamine receptors in the striatal direct and indirect pathways: An historical perspective

The direct and indirect striatal pathways form a cornerstone of the circuits of the basal ganglia. Dopamine has opponent affects on the function of these pathways due to the segregation of the D1- and D2-dopamine receptors in the spiny projection neurons giving rise to the direct and indirect pathwa...

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Detalles Bibliográficos
Autor principal: Gerfen, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Synaptic Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892636/
https://www.ncbi.nlm.nih.gov/pubmed/36741471
http://dx.doi.org/10.3389/fnsyn.2022.1002960
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author Gerfen, Charles R.
author_facet Gerfen, Charles R.
author_sort Gerfen, Charles R.
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description The direct and indirect striatal pathways form a cornerstone of the circuits of the basal ganglia. Dopamine has opponent affects on the function of these pathways due to the segregation of the D1- and D2-dopamine receptors in the spiny projection neurons giving rise to the direct and indirect pathways. An historical perspective is provided on the discovery of dopamine receptor segregation leading to models of how the direct and indirect affect motor behavior.
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spelling pubmed-98926362023-02-03 Segregation of D1 and D2 dopamine receptors in the striatal direct and indirect pathways: An historical perspective Gerfen, Charles R. Front Synaptic Neurosci Synaptic Neuroscience The direct and indirect striatal pathways form a cornerstone of the circuits of the basal ganglia. Dopamine has opponent affects on the function of these pathways due to the segregation of the D1- and D2-dopamine receptors in the spiny projection neurons giving rise to the direct and indirect pathways. An historical perspective is provided on the discovery of dopamine receptor segregation leading to models of how the direct and indirect affect motor behavior. Frontiers Media S.A. 2023-01-19 /pmc/articles/PMC9892636/ /pubmed/36741471 http://dx.doi.org/10.3389/fnsyn.2022.1002960 Text en Copyright © 2023 This work is authored by Charles R. Gerfen on behalf of the U.S. Government and as regards Dr. Gerfen, and the U.S. Government, is not subject to copyright protection in the United States. Foreign and other copyrights may apply. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Synaptic Neuroscience
Gerfen, Charles R.
Segregation of D1 and D2 dopamine receptors in the striatal direct and indirect pathways: An historical perspective
title Segregation of D1 and D2 dopamine receptors in the striatal direct and indirect pathways: An historical perspective
title_full Segregation of D1 and D2 dopamine receptors in the striatal direct and indirect pathways: An historical perspective
title_fullStr Segregation of D1 and D2 dopamine receptors in the striatal direct and indirect pathways: An historical perspective
title_full_unstemmed Segregation of D1 and D2 dopamine receptors in the striatal direct and indirect pathways: An historical perspective
title_short Segregation of D1 and D2 dopamine receptors in the striatal direct and indirect pathways: An historical perspective
title_sort segregation of d1 and d2 dopamine receptors in the striatal direct and indirect pathways: an historical perspective
topic Synaptic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892636/
https://www.ncbi.nlm.nih.gov/pubmed/36741471
http://dx.doi.org/10.3389/fnsyn.2022.1002960
work_keys_str_mv AT gerfencharlesr segregationofd1andd2dopaminereceptorsinthestriataldirectandindirectpathwaysanhistoricalperspective

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