Vam6 reduces iNKT cell function in tumor via modulating AMPK/mTOR pathways

Activation of mTORC1 is essential for anti-tumor function of iNKT cells. The mechanisms underlying impaired mTORC1 activation in intratumoral iNKT cells remain unclear. Via generating Vam6(+/-) mice and using flow cytometry, image approach, and RNA sequencing, we studied the role of Vam6 in controll...

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Detalles Bibliográficos
Autores principales: Bai, Shiyu, Wu, Qielan, Zhu, Shasha, Zhang, Yuwei, Chen, Xuran, Su, Miya, Pan, Jun, Li, Shuhang, Yue, Ting, Xu, Linfeng, Xie, Di, Tian, Chenxi, Zhao, Dan, Li, Xiang, Hou, Junjie, Wang, Lu, Fu, Sicheng, Xue, Yanhong, Jiang, Amin, Li, Dong, Xu, Tao, Tian, Zhigang, Zhou, Rongbin, Zhang, Huimin, Bai, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892639/
https://www.ncbi.nlm.nih.gov/pubmed/36741382
http://dx.doi.org/10.3389/fimmu.2022.1051045

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