High-throughput screening method for discovering CatSper inhibitors using membrane depolarization caused by external calcium chelation and fluorescent cell barcoding

The exclusive expression of CatSper in sperm and its critical role in sperm function makes this channel an attractive target for contraception. The strategy of blocking CatSper as a male, non-hormonal contraceptive has not been fully explored due to the lack of robust screening methods to discover n...

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Detalles Bibliográficos
Autores principales: Luque, Guillermina M., Schiavi-Ehrenhaus, Liza J., Jabloñski, Martina, Balestrini, Paula A., Novero, Analia G., Torres, Nicolás I., Osycka-Salut, Claudia E., Darszon, Alberto, Krapf, Dario, Buffone, Mariano G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892719/
https://www.ncbi.nlm.nih.gov/pubmed/36743410
http://dx.doi.org/10.3389/fcell.2023.1010306

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