Isoniazid improves cognitive performance, clears Aβ plaques, and protects dendritic synapses in APP/PS1 transgenic mice

BACKGROUND AND OBJECTIVE: Alzheimer’s disease (AD) is characterized by amyloid β (Aβ) aggregation and neuroinflammation. This study aimed to investigate the therapeutic effect of isoniazid (INH) against AD. METHODS: The APP/PS1 transgenic mouse model of AD was adopted. The APP/PS1 mice received oral...

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Detalles Bibliográficos
Autores principales: Chen, Jiacheng, Guo, Ning, Ruan, Yuting, Mai, Yingren, Liao, Wang, Feng, Yanqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892762/
https://www.ncbi.nlm.nih.gov/pubmed/36743440
http://dx.doi.org/10.3389/fnagi.2023.1105095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892762/
https://www.ncbi.nlm.nih.gov/pubmed/36743440
http://dx.doi.org/10.3389/fnagi.2023.1105095

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