Probabilistic integration of transcriptome-wide association studies and colocalization analysis identifies key molecular pathways of complex traits

Integrative genetic association methods have shown great promise in post-GWAS (genome-wide association study) analyses, in which one of the most challenging tasks is identifying putative causal genes and uncovering molecular mechanisms of complex traits. Recent studies suggest that prevailing comput...

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Detalles Bibliográficos
Autores principales: Okamoto, Jeffrey, Wang, Lijia, Yin, Xianyong, Luca, Francesca, Pique-Regi, Roger, Helms, Adam, Im, Hae Kyung, Morrison, Jean, Wen, Xiaoquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892769/
https://www.ncbi.nlm.nih.gov/pubmed/36608684
http://dx.doi.org/10.1016/j.ajhg.2022.12.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892769/
https://www.ncbi.nlm.nih.gov/pubmed/36608684
http://dx.doi.org/10.1016/j.ajhg.2022.12.002

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