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Probabilistic integration of transcriptome-wide association studies and colocalization analysis identifies key molecular pathways of complex traits
Integrative genetic association methods have shown great promise in post-GWAS (genome-wide association study) analyses, in which one of the most challenging tasks is identifying putative causal genes and uncovering molecular mechanisms of complex traits. Recent studies suggest that prevailing comput...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892769/ https://www.ncbi.nlm.nih.gov/pubmed/36608684 http://dx.doi.org/10.1016/j.ajhg.2022.12.002 |