RNA m(6)A methylation in cancer

N (6) ‐methyladenosine (m(6)A) is one of the most abundant internal modifications in eukaryotic messenger RNAs (mRNAs) and non‐coding RNAs (ncRNAs). It is a reversible and dynamic RNA modification that has been observed in both internal coding segments and untranslated regions. Studies indicate that...

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Autores principales: Wang, Zhaotong, Zhou, Jiawang, Zhang, Haisheng, Ge, Lichen, Li, Jiexin, Wang, Hongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892831/
https://www.ncbi.nlm.nih.gov/pubmed/36260366
http://dx.doi.org/10.1002/1878-0261.13326
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author Wang, Zhaotong
Zhou, Jiawang
Zhang, Haisheng
Ge, Lichen
Li, Jiexin
Wang, Hongsheng
author_facet Wang, Zhaotong
Zhou, Jiawang
Zhang, Haisheng
Ge, Lichen
Li, Jiexin
Wang, Hongsheng
author_sort Wang, Zhaotong
collection PubMed
description N (6) ‐methyladenosine (m(6)A) is one of the most abundant internal modifications in eukaryotic messenger RNAs (mRNAs) and non‐coding RNAs (ncRNAs). It is a reversible and dynamic RNA modification that has been observed in both internal coding segments and untranslated regions. Studies indicate that m(6)A modifications play important roles in translation, RNA splicing, export, degradation and ncRNA processing control. In this review, we focus on the profiles and biological functions of RNA m(6)A methylation on both mRNAs and ncRNAs. The dynamic modification of m(6)A and its potential roles in cancer development are discussed. Moreover, we discuss the possibility of m(6)A modifications serving as potential biomarkers for cancer diagnosis and targets for therapy.
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spelling pubmed-98928312023-02-06 RNA m(6)A methylation in cancer Wang, Zhaotong Zhou, Jiawang Zhang, Haisheng Ge, Lichen Li, Jiexin Wang, Hongsheng Mol Oncol Review N (6) ‐methyladenosine (m(6)A) is one of the most abundant internal modifications in eukaryotic messenger RNAs (mRNAs) and non‐coding RNAs (ncRNAs). It is a reversible and dynamic RNA modification that has been observed in both internal coding segments and untranslated regions. Studies indicate that m(6)A modifications play important roles in translation, RNA splicing, export, degradation and ncRNA processing control. In this review, we focus on the profiles and biological functions of RNA m(6)A methylation on both mRNAs and ncRNAs. The dynamic modification of m(6)A and its potential roles in cancer development are discussed. Moreover, we discuss the possibility of m(6)A modifications serving as potential biomarkers for cancer diagnosis and targets for therapy. John Wiley and Sons Inc. 2022-11-06 /pmc/articles/PMC9892831/ /pubmed/36260366 http://dx.doi.org/10.1002/1878-0261.13326 Text en © 2022 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Wang, Zhaotong
Zhou, Jiawang
Zhang, Haisheng
Ge, Lichen
Li, Jiexin
Wang, Hongsheng
RNA m(6)A methylation in cancer
title RNA m(6)A methylation in cancer
title_full RNA m(6)A methylation in cancer
title_fullStr RNA m(6)A methylation in cancer
title_full_unstemmed RNA m(6)A methylation in cancer
title_short RNA m(6)A methylation in cancer
title_sort rna m(6)a methylation in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892831/
https://www.ncbi.nlm.nih.gov/pubmed/36260366
http://dx.doi.org/10.1002/1878-0261.13326
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AT lijiexin rnam6amethylationincancer
AT wanghongsheng rnam6amethylationincancer

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