Cargando…
Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry
In 2017, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of deoxynivalenol (DON) and its acetylated and modified forms in food and feed. No observed adverse effect levels (NOAELs) and lowest observed advers...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892893/ https://www.ncbi.nlm.nih.gov/pubmed/36751491 http://dx.doi.org/10.2903/j.efsa.2023.7806 |
_version_ | 1784881407390121984 |
---|---|
author | Schrenk, Dieter Bignami, Margherita Bodin, Laurent del Mazo, James Kevin Chipman Jesús Grasl‐Kraupp, Bettina Hogstrand, Christer Leblanc, Jean‐Charles Nielsen, Elsa Ntzani, Evangelia Petersen, Annette Sand, Salomon Schwerdtle, Tanja Vleminckx, Christiane Wallace, Heather Dänicke, Sven Nebbia, Carlo Stefano Oswald, Isabelle P Rovesti, Elena Steinkellner, Hans Hoogenboom, Laurentius (Ron) |
author_facet | Schrenk, Dieter Bignami, Margherita Bodin, Laurent del Mazo, James Kevin Chipman Jesús Grasl‐Kraupp, Bettina Hogstrand, Christer Leblanc, Jean‐Charles Nielsen, Elsa Ntzani, Evangelia Petersen, Annette Sand, Salomon Schwerdtle, Tanja Vleminckx, Christiane Wallace, Heather Dänicke, Sven Nebbia, Carlo Stefano Oswald, Isabelle P Rovesti, Elena Steinkellner, Hans Hoogenboom, Laurentius (Ron) |
collection | PubMed |
description | In 2017, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of deoxynivalenol (DON) and its acetylated and modified forms in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. For horses, an NOAEL of 36 mg DON/kg feed was established, the highest concentration tested and not showing adverse effects. For poultry, an NOAEL of 5 mg DON/kg feed for broiler chickens and laying hens, and an NOAEL of 7 mg DON/kg feed for ducks and turkeys was derived. The European Commission requested EFSA to review the information regarding the toxicity of DON for horses and poultry and to revise, if necessary, the established reference points (RPs). Adverse effect levels of 1.9 and 1.7 mg DON/kg feed for, respectively, broiler chickens and turkeys were derived from reassessment of existing studies and newly available literature, showing that DON causes effects on the intestines, in particular the jejunum, with a decreased villus height but also histological damage. An RP for adverse animal health effects of 0.6 mg/kg feed for broiler chickens and turkeys, respectively, was established. For horses, an adverse effect level of 5.6 mg DON/kg feed was established from studies showing reduced feed intake, with an RP for adverse animal health effects of 3.5 mg/kg feed. For ducks and laying hens, RPs remain unchanged. Based on mean and P95 (UB) exposure estimates performed in the previous Opinion, the risk of adverse health effects of feeds containing DON was considered a potential concern for broiler chickens and turkeys. For horses, the risk for adverse health effects from feed containing DON is low. |
format | Online Article Text |
id | pubmed-9892893 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98928932023-02-06 Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry Schrenk, Dieter Bignami, Margherita Bodin, Laurent del Mazo, James Kevin Chipman Jesús Grasl‐Kraupp, Bettina Hogstrand, Christer Leblanc, Jean‐Charles Nielsen, Elsa Ntzani, Evangelia Petersen, Annette Sand, Salomon Schwerdtle, Tanja Vleminckx, Christiane Wallace, Heather Dänicke, Sven Nebbia, Carlo Stefano Oswald, Isabelle P Rovesti, Elena Steinkellner, Hans Hoogenboom, Laurentius (Ron) EFSA J Scientific Opinion In 2017, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of deoxynivalenol (DON) and its acetylated and modified forms in food and feed. No observed adverse effect levels (NOAELs) and lowest observed adverse effect levels (LOAELs) were derived for different animal species. For horses, an NOAEL of 36 mg DON/kg feed was established, the highest concentration tested and not showing adverse effects. For poultry, an NOAEL of 5 mg DON/kg feed for broiler chickens and laying hens, and an NOAEL of 7 mg DON/kg feed for ducks and turkeys was derived. The European Commission requested EFSA to review the information regarding the toxicity of DON for horses and poultry and to revise, if necessary, the established reference points (RPs). Adverse effect levels of 1.9 and 1.7 mg DON/kg feed for, respectively, broiler chickens and turkeys were derived from reassessment of existing studies and newly available literature, showing that DON causes effects on the intestines, in particular the jejunum, with a decreased villus height but also histological damage. An RP for adverse animal health effects of 0.6 mg/kg feed for broiler chickens and turkeys, respectively, was established. For horses, an adverse effect level of 5.6 mg DON/kg feed was established from studies showing reduced feed intake, with an RP for adverse animal health effects of 3.5 mg/kg feed. For ducks and laying hens, RPs remain unchanged. Based on mean and P95 (UB) exposure estimates performed in the previous Opinion, the risk of adverse health effects of feeds containing DON was considered a potential concern for broiler chickens and turkeys. For horses, the risk for adverse health effects from feed containing DON is low. John Wiley and Sons Inc. 2023-02-02 /pmc/articles/PMC9892893/ /pubmed/36751491 http://dx.doi.org/10.2903/j.efsa.2023.7806 Text en © 2023 Wiley‐VCH Verlag GmbH & Co. KgaA on behalf of the European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
spellingShingle | Scientific Opinion Schrenk, Dieter Bignami, Margherita Bodin, Laurent del Mazo, James Kevin Chipman Jesús Grasl‐Kraupp, Bettina Hogstrand, Christer Leblanc, Jean‐Charles Nielsen, Elsa Ntzani, Evangelia Petersen, Annette Sand, Salomon Schwerdtle, Tanja Vleminckx, Christiane Wallace, Heather Dänicke, Sven Nebbia, Carlo Stefano Oswald, Isabelle P Rovesti, Elena Steinkellner, Hans Hoogenboom, Laurentius (Ron) Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry |
title | Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry |
title_full | Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry |
title_fullStr | Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry |
title_full_unstemmed | Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry |
title_short | Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry |
title_sort | assessment of information as regards the toxicity of deoxynivalenol for horses and poultry |
topic | Scientific Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892893/ https://www.ncbi.nlm.nih.gov/pubmed/36751491 http://dx.doi.org/10.2903/j.efsa.2023.7806 |
work_keys_str_mv | AT assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT schrenkdieter assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT bignamimargherita assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT bodinlaurent assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT delmazojameskevinchipmanjesus assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT graslkrauppbettina assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT hogstrandchrister assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT leblancjeancharles assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT nielsenelsa assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT ntzanievangelia assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT petersenannette assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT sandsalomon assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT schwerdtletanja assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT vleminckxchristiane assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT wallaceheather assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT danickesven assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT nebbiacarlostefano assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT oswaldisabellep assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT rovestielena assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT steinkellnerhans assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry AT hoogenboomlaurentiusron assessmentofinformationasregardsthetoxicityofdeoxynivalenolforhorsesandpoultry |