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Electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel

The poor solubility of numerous drugs pose a long-existing challenge to the researchers in the fields of pharmaceutics, bioengineering and biotechnology. Many “top-down” and “bottom-up” nano fabrication methods have been exploited to provide solutions for this issue. In this study, a combination str...

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Autores principales: Ge, Ruiliang, Ji, Yuexin, Ding, Yanfei, Huang, Chang, He, Hua, Yu, Deng-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892910/
https://www.ncbi.nlm.nih.gov/pubmed/36741747
http://dx.doi.org/10.3389/fbioe.2023.1112338
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author Ge, Ruiliang
Ji, Yuexin
Ding, Yanfei
Huang, Chang
He, Hua
Yu, Deng-Guang
author_facet Ge, Ruiliang
Ji, Yuexin
Ding, Yanfei
Huang, Chang
He, Hua
Yu, Deng-Guang
author_sort Ge, Ruiliang
collection PubMed
description The poor solubility of numerous drugs pose a long-existing challenge to the researchers in the fields of pharmaceutics, bioengineering and biotechnology. Many “top-down” and “bottom-up” nano fabrication methods have been exploited to provide solutions for this issue. In this study, a combination strategy of top-down process (electrospinning) and bottom-up (self-emulsifying) was demonstrated to be useful for enhancing the dissolution of a typical poorly water-soluble anticancer model drug (paclitaxel, PTX). With polyvinylpyrrolidone (PVP K90) as the filament-forming matrix and drug carrier, polyoxyethylene castor oil (PCO) as emulsifier, and triglyceride (TG) as oil phase, Both a single-fluid blending process and a coaxial process were utilized to prepare medicated nanofibers. Scanning electron microscope and transmission electron microscope (TEM) results clearly demonstrated the morphology and inner structures of the nanofibers. The lipid nanoparticles of emulsions after self-emulsification were also assessed through TEM. The encapsulation efficiency (EE) and in vitro dissolution tests demonstrated that the cores-shell nanofibers could provide a better self-emulsifying process int terms of a higher EE and a better drug sustained release profile. Meanwhile, an increase of sheath fluid rate could benefit an even better results, suggesting a clear process-property-performance relationship. The protocols reported here pave anew way for effective oral delivery of poorly water-soluble drug.
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spelling pubmed-98929102023-02-03 Electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel Ge, Ruiliang Ji, Yuexin Ding, Yanfei Huang, Chang He, Hua Yu, Deng-Guang Front Bioeng Biotechnol Bioengineering and Biotechnology The poor solubility of numerous drugs pose a long-existing challenge to the researchers in the fields of pharmaceutics, bioengineering and biotechnology. Many “top-down” and “bottom-up” nano fabrication methods have been exploited to provide solutions for this issue. In this study, a combination strategy of top-down process (electrospinning) and bottom-up (self-emulsifying) was demonstrated to be useful for enhancing the dissolution of a typical poorly water-soluble anticancer model drug (paclitaxel, PTX). With polyvinylpyrrolidone (PVP K90) as the filament-forming matrix and drug carrier, polyoxyethylene castor oil (PCO) as emulsifier, and triglyceride (TG) as oil phase, Both a single-fluid blending process and a coaxial process were utilized to prepare medicated nanofibers. Scanning electron microscope and transmission electron microscope (TEM) results clearly demonstrated the morphology and inner structures of the nanofibers. The lipid nanoparticles of emulsions after self-emulsification were also assessed through TEM. The encapsulation efficiency (EE) and in vitro dissolution tests demonstrated that the cores-shell nanofibers could provide a better self-emulsifying process int terms of a higher EE and a better drug sustained release profile. Meanwhile, an increase of sheath fluid rate could benefit an even better results, suggesting a clear process-property-performance relationship. The protocols reported here pave anew way for effective oral delivery of poorly water-soluble drug. Frontiers Media S.A. 2023-01-19 /pmc/articles/PMC9892910/ /pubmed/36741747 http://dx.doi.org/10.3389/fbioe.2023.1112338 Text en Copyright © 2023 Ge, Ji, Ding, Huang, He and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Ge, Ruiliang
Ji, Yuexin
Ding, Yanfei
Huang, Chang
He, Hua
Yu, Deng-Guang
Electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel
title Electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel
title_full Electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel
title_fullStr Electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel
title_full_unstemmed Electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel
title_short Electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel
title_sort electrospun self-emulsifying core-shell nanofibers for effective delivery of paclitaxel
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892910/
https://www.ncbi.nlm.nih.gov/pubmed/36741747
http://dx.doi.org/10.3389/fbioe.2023.1112338
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