Cargando…
Lymphoscintigraphy Using Tilmanocept Detects Multiple Sentinel Lymph Nodes in Melanoma Patients
BACKGROUND: Technetium-99m-labeled Tilmanocept, a multivalent mannose, is readily internalized by the CD206 surface receptor on macrophages and dendritic cells which are abundantly present in lymph nodes. We want to examine the drainage patterns of Technetium-99m-labeled Tilmanocept to sentinel lymp...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893075/ https://www.ncbi.nlm.nih.gov/pubmed/36705261 http://dx.doi.org/10.1177/10732748231153775 |
_version_ | 1784881449001811968 |
---|---|
author | Balkin, Daniel M. Tranah, Gregory J. Wang, Frederick O’Donoghue, Cristina Morell, Emily A. Porubsky, Caitlin Nosrati, Mehdi Vaquero, Edith M. Kim, HanKyul Carr, Michael J. Montilla-Soler, Jaime L. Wu, Max C. Torre, Donald M. Kashani-Sabet, Mohammed Zager, Jonathan S. Leong, Stanley P. |
author_facet | Balkin, Daniel M. Tranah, Gregory J. Wang, Frederick O’Donoghue, Cristina Morell, Emily A. Porubsky, Caitlin Nosrati, Mehdi Vaquero, Edith M. Kim, HanKyul Carr, Michael J. Montilla-Soler, Jaime L. Wu, Max C. Torre, Donald M. Kashani-Sabet, Mohammed Zager, Jonathan S. Leong, Stanley P. |
author_sort | Balkin, Daniel M. |
collection | PubMed |
description | BACKGROUND: Technetium-99m-labeled Tilmanocept, a multivalent mannose, is readily internalized by the CD206 surface receptor on macrophages and dendritic cells which are abundantly present in lymph nodes. We want to examine the drainage patterns of Technetium-99m-labeled Tilmanocept to sentinel lymph nodes (SLNs) in melanoma patients following the 10% rule. METHODS: Multi-center retrospective review of patients with cutaneous melanoma undergoing SLN biopsy using Technetium-99m-labeled Tilmanocept between 2008 and 2014 was conducted. Statistical methods were used for data analyses. RESULTS: Of the 564 patients (mean age of 60.3 and 62% male) with preoperative lymphoscintigraphy showing at least one SLN, several primary tumor sites were included: 27% head/neck, 33% trunk, 21% upper extremity and 19% lower extremity. For the head/neck primary site, 36.5% of patients had multiple draining basins; for the trunk site, 36.4% of patients; for the upper extremity site, 13% of patients; and for the lower extremity, 27.4% of patients. A median of 3 (range 1-18) SLNs were identified and resected. Overall, 78% of patients had >1 SLN identified by Technetium-99m-labeled Tilmanocept. In a multivariate model, patients with >1 SLN were significantly associated with age, Breslow depth, tumor location and higher AJCC tumor stage. A total of 17.7% of patients (100/564) had a positive SLN identified. A total of 145 positive SLNs were identified out of 1,812 SLNs with a positive SLN rate of 8%. Positive SLN status was significantly associated with younger age, greater Breslow depth, mitosis rate, higher AJCC tumor stage, presence of ulceration and angiolymphatic invasion. CONCLUSIONS: Using the 10% rule, Technetium-99m-labeled Tilmanocept detects multiple SLNs in most melanoma patients. |
format | Online Article Text |
id | pubmed-9893075 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-98930752023-02-03 Lymphoscintigraphy Using Tilmanocept Detects Multiple Sentinel Lymph Nodes in Melanoma Patients Balkin, Daniel M. Tranah, Gregory J. Wang, Frederick O’Donoghue, Cristina Morell, Emily A. Porubsky, Caitlin Nosrati, Mehdi Vaquero, Edith M. Kim, HanKyul Carr, Michael J. Montilla-Soler, Jaime L. Wu, Max C. Torre, Donald M. Kashani-Sabet, Mohammed Zager, Jonathan S. Leong, Stanley P. Cancer Control Original Research Article BACKGROUND: Technetium-99m-labeled Tilmanocept, a multivalent mannose, is readily internalized by the CD206 surface receptor on macrophages and dendritic cells which are abundantly present in lymph nodes. We want to examine the drainage patterns of Technetium-99m-labeled Tilmanocept to sentinel lymph nodes (SLNs) in melanoma patients following the 10% rule. METHODS: Multi-center retrospective review of patients with cutaneous melanoma undergoing SLN biopsy using Technetium-99m-labeled Tilmanocept between 2008 and 2014 was conducted. Statistical methods were used for data analyses. RESULTS: Of the 564 patients (mean age of 60.3 and 62% male) with preoperative lymphoscintigraphy showing at least one SLN, several primary tumor sites were included: 27% head/neck, 33% trunk, 21% upper extremity and 19% lower extremity. For the head/neck primary site, 36.5% of patients had multiple draining basins; for the trunk site, 36.4% of patients; for the upper extremity site, 13% of patients; and for the lower extremity, 27.4% of patients. A median of 3 (range 1-18) SLNs were identified and resected. Overall, 78% of patients had >1 SLN identified by Technetium-99m-labeled Tilmanocept. In a multivariate model, patients with >1 SLN were significantly associated with age, Breslow depth, tumor location and higher AJCC tumor stage. A total of 17.7% of patients (100/564) had a positive SLN identified. A total of 145 positive SLNs were identified out of 1,812 SLNs with a positive SLN rate of 8%. Positive SLN status was significantly associated with younger age, greater Breslow depth, mitosis rate, higher AJCC tumor stage, presence of ulceration and angiolymphatic invasion. CONCLUSIONS: Using the 10% rule, Technetium-99m-labeled Tilmanocept detects multiple SLNs in most melanoma patients. SAGE Publications 2023-01-27 /pmc/articles/PMC9893075/ /pubmed/36705261 http://dx.doi.org/10.1177/10732748231153775 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Article Balkin, Daniel M. Tranah, Gregory J. Wang, Frederick O’Donoghue, Cristina Morell, Emily A. Porubsky, Caitlin Nosrati, Mehdi Vaquero, Edith M. Kim, HanKyul Carr, Michael J. Montilla-Soler, Jaime L. Wu, Max C. Torre, Donald M. Kashani-Sabet, Mohammed Zager, Jonathan S. Leong, Stanley P. Lymphoscintigraphy Using Tilmanocept Detects Multiple Sentinel Lymph Nodes in Melanoma Patients |
title | Lymphoscintigraphy Using Tilmanocept Detects Multiple Sentinel Lymph Nodes in Melanoma Patients |
title_full | Lymphoscintigraphy Using Tilmanocept Detects Multiple Sentinel Lymph Nodes in Melanoma Patients |
title_fullStr | Lymphoscintigraphy Using Tilmanocept Detects Multiple Sentinel Lymph Nodes in Melanoma Patients |
title_full_unstemmed | Lymphoscintigraphy Using Tilmanocept Detects Multiple Sentinel Lymph Nodes in Melanoma Patients |
title_short | Lymphoscintigraphy Using Tilmanocept Detects Multiple Sentinel Lymph Nodes in Melanoma Patients |
title_sort | lymphoscintigraphy using tilmanocept detects multiple sentinel lymph nodes in melanoma patients |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893075/ https://www.ncbi.nlm.nih.gov/pubmed/36705261 http://dx.doi.org/10.1177/10732748231153775 |
work_keys_str_mv | AT balkindanielm lymphoscintigraphyusingtilmanoceptdetectsmultiplesentinellymphnodesinmelanomapatients AT tranahgregoryj lymphoscintigraphyusingtilmanoceptdetectsmultiplesentinellymphnodesinmelanomapatients AT wangfrederick lymphoscintigraphyusingtilmanoceptdetectsmultiplesentinellymphnodesinmelanomapatients AT odonoghuecristina lymphoscintigraphyusingtilmanoceptdetectsmultiplesentinellymphnodesinmelanomapatients AT morellemilya lymphoscintigraphyusingtilmanoceptdetectsmultiplesentinellymphnodesinmelanomapatients AT porubskycaitlin lymphoscintigraphyusingtilmanoceptdetectsmultiplesentinellymphnodesinmelanomapatients AT nosratimehdi lymphoscintigraphyusingtilmanoceptdetectsmultiplesentinellymphnodesinmelanomapatients AT vaqueroedithm lymphoscintigraphyusingtilmanoceptdetectsmultiplesentinellymphnodesinmelanomapatients AT kimhankyul lymphoscintigraphyusingtilmanoceptdetectsmultiplesentinellymphnodesinmelanomapatients AT carrmichaelj lymphoscintigraphyusingtilmanoceptdetectsmultiplesentinellymphnodesinmelanomapatients AT montillasolerjaimel lymphoscintigraphyusingtilmanoceptdetectsmultiplesentinellymphnodesinmelanomapatients AT wumaxc lymphoscintigraphyusingtilmanoceptdetectsmultiplesentinellymphnodesinmelanomapatients AT torredonaldm lymphoscintigraphyusingtilmanoceptdetectsmultiplesentinellymphnodesinmelanomapatients AT kashanisabetmohammed lymphoscintigraphyusingtilmanoceptdetectsmultiplesentinellymphnodesinmelanomapatients AT zagerjonathans lymphoscintigraphyusingtilmanoceptdetectsmultiplesentinellymphnodesinmelanomapatients AT leongstanleyp lymphoscintigraphyusingtilmanoceptdetectsmultiplesentinellymphnodesinmelanomapatients |