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Characteristics, risk factors, and outcomes of bloodstream Candida infections in the intensive care unit: a retrospective cohort study

OBJECTIVE: The main objective was to assess the clinical characteristics, associated factors, and outcomes of patients admitted to the ICU for candidemia. The secondary objective was to examine the relationship of candidemia with the length of stay and mortality. METHODS: The analysis was a retrospe...

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Autores principales: Hohmann, Fábio Barlem, Chaves, Renato Carneiro de Freitas, Olivato, Guilherme Benfatti, de Souza, Guilherme Martins, Galindo, Vinicius Barbosa, Silva Jr, Moacyr, Martino, Marines Dalla Valle, de Menezes, Fernando Gatti, Corrêa, Thiago Domingos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893083/
https://www.ncbi.nlm.nih.gov/pubmed/36659829
http://dx.doi.org/10.1177/03000605221131122
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author Hohmann, Fábio Barlem
Chaves, Renato Carneiro de Freitas
Olivato, Guilherme Benfatti
de Souza, Guilherme Martins
Galindo, Vinicius Barbosa
Silva Jr, Moacyr
Martino, Marines Dalla Valle
de Menezes, Fernando Gatti
Corrêa, Thiago Domingos
author_facet Hohmann, Fábio Barlem
Chaves, Renato Carneiro de Freitas
Olivato, Guilherme Benfatti
de Souza, Guilherme Martins
Galindo, Vinicius Barbosa
Silva Jr, Moacyr
Martino, Marines Dalla Valle
de Menezes, Fernando Gatti
Corrêa, Thiago Domingos
author_sort Hohmann, Fábio Barlem
collection PubMed
description OBJECTIVE: The main objective was to assess the clinical characteristics, associated factors, and outcomes of patients admitted to the ICU for candidemia. The secondary objective was to examine the relationship of candidemia with the length of stay and mortality. METHODS: The analysis was a retrospective single-center cohort study addressing the effect of invasive candidemia on outcomes. This study was performed in a medical-surgical ICU located in a tertiary private hospital in São Paulo, Brazil. Data was collected through the review of the hospital database. RESULTS: In total, 18,442 patients were included in our study, including 22 patients with candidemia. The median age was similar in patients with and without candidemia [67 (56–84) vs. 67 (51–80)]. Most patients were male, and the proportion of men was higher among patients with candidemia (77% vs. 55.3%). The rates of renal replacement therapy (40.9% vs. 3.3%), mechanical ventilation (63.6% vs. 29.6%), and parenteral nutrition (40.9% vs. 4.8%) were higher in patients with candidemia than in those without candidemia. The mortality rate (77.3% vs. 11.9%) and length of hospital stay [42 days (23.0–78.8) vs. 8 days (5.0–17.0)] were significantly higher in patients with candidemia. CONCLUSIONS: Patients with candidemia are prone to longer hospital stay and mortality. In addition, we found associations of candidemia with the use of invasive mechanical ventilation, renal replacement therapy, and parenteral nutrition.
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spelling pubmed-98930832023-02-03 Characteristics, risk factors, and outcomes of bloodstream Candida infections in the intensive care unit: a retrospective cohort study Hohmann, Fábio Barlem Chaves, Renato Carneiro de Freitas Olivato, Guilherme Benfatti de Souza, Guilherme Martins Galindo, Vinicius Barbosa Silva Jr, Moacyr Martino, Marines Dalla Valle de Menezes, Fernando Gatti Corrêa, Thiago Domingos J Int Med Res Retrospective Clinical Research Report OBJECTIVE: The main objective was to assess the clinical characteristics, associated factors, and outcomes of patients admitted to the ICU for candidemia. The secondary objective was to examine the relationship of candidemia with the length of stay and mortality. METHODS: The analysis was a retrospective single-center cohort study addressing the effect of invasive candidemia on outcomes. This study was performed in a medical-surgical ICU located in a tertiary private hospital in São Paulo, Brazil. Data was collected through the review of the hospital database. RESULTS: In total, 18,442 patients were included in our study, including 22 patients with candidemia. The median age was similar in patients with and without candidemia [67 (56–84) vs. 67 (51–80)]. Most patients were male, and the proportion of men was higher among patients with candidemia (77% vs. 55.3%). The rates of renal replacement therapy (40.9% vs. 3.3%), mechanical ventilation (63.6% vs. 29.6%), and parenteral nutrition (40.9% vs. 4.8%) were higher in patients with candidemia than in those without candidemia. The mortality rate (77.3% vs. 11.9%) and length of hospital stay [42 days (23.0–78.8) vs. 8 days (5.0–17.0)] were significantly higher in patients with candidemia. CONCLUSIONS: Patients with candidemia are prone to longer hospital stay and mortality. In addition, we found associations of candidemia with the use of invasive mechanical ventilation, renal replacement therapy, and parenteral nutrition. SAGE Publications 2023-01-19 /pmc/articles/PMC9893083/ /pubmed/36659829 http://dx.doi.org/10.1177/03000605221131122 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Retrospective Clinical Research Report
Hohmann, Fábio Barlem
Chaves, Renato Carneiro de Freitas
Olivato, Guilherme Benfatti
de Souza, Guilherme Martins
Galindo, Vinicius Barbosa
Silva Jr, Moacyr
Martino, Marines Dalla Valle
de Menezes, Fernando Gatti
Corrêa, Thiago Domingos
Characteristics, risk factors, and outcomes of bloodstream Candida infections in the intensive care unit: a retrospective cohort study
title Characteristics, risk factors, and outcomes of bloodstream Candida infections in the intensive care unit: a retrospective cohort study
title_full Characteristics, risk factors, and outcomes of bloodstream Candida infections in the intensive care unit: a retrospective cohort study
title_fullStr Characteristics, risk factors, and outcomes of bloodstream Candida infections in the intensive care unit: a retrospective cohort study
title_full_unstemmed Characteristics, risk factors, and outcomes of bloodstream Candida infections in the intensive care unit: a retrospective cohort study
title_short Characteristics, risk factors, and outcomes of bloodstream Candida infections in the intensive care unit: a retrospective cohort study
title_sort characteristics, risk factors, and outcomes of bloodstream candida infections in the intensive care unit: a retrospective cohort study
topic Retrospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893083/
https://www.ncbi.nlm.nih.gov/pubmed/36659829
http://dx.doi.org/10.1177/03000605221131122
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