Click Chemistry-Generated Auristatin F–Linker–Benzylguanine for a SNAP-Tag-Based Recombinant Antibody–Drug Conjugate Demonstrating Selective Cytotoxicity toward EGFR-Overexpressing Tumor Cells

[Image: see text] Antibody–drug conjugates (ADCs) are bifunctional molecules combining the targeting potential of monoclonal antibodies with the cancer-killing ability of cytotoxic drugs. This simple yet intelligently designed system directly addresses the lack of specificity encountered with conven...

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Detalles Bibliográficos
Autores principales: Huysamen, Allan M., Fadeyi, Olaolu E., Mayuni, Grace, Dogbey, Dennis M., Mungra, Neelakshi, Biteghe, Fleury A. N., Hardcastle, Natasha, Ramamurthy, Dharanidharan, Akinrinmade, Olusiji A., Naran, Krupa, Cooper, Susan, Lang, Dirk, Richter, Wolfgang, Hunter, Roger, Barth, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893251/
https://www.ncbi.nlm.nih.gov/pubmed/36743041
http://dx.doi.org/10.1021/acsomega.2c06844

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