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Diagnostic and therapeutic value of biomarkers in urosepsis

Urosepsis is sepsis caused by urogenital tract infection and is one of the most common critical illnesses in urology. If urosepsis is not diagnosed early, it can rapidly progress and worsen, leading to increased mortality. In recent years, with the increase of urinary tract surgery, the incidence of...

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Autores principales: Wu, Yuyun, Wang, Guang, Huang, Ziye, Yang, Bowei, Yang, Tongxin, Liu, Jianhe, Li, Pei, Li, Jiongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893402/
https://www.ncbi.nlm.nih.gov/pubmed/36744043
http://dx.doi.org/10.1177/17562872231151852
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author Wu, Yuyun
Wang, Guang
Huang, Ziye
Yang, Bowei
Yang, Tongxin
Liu, Jianhe
Li, Pei
Li, Jiongming
author_facet Wu, Yuyun
Wang, Guang
Huang, Ziye
Yang, Bowei
Yang, Tongxin
Liu, Jianhe
Li, Pei
Li, Jiongming
author_sort Wu, Yuyun
collection PubMed
description Urosepsis is sepsis caused by urogenital tract infection and is one of the most common critical illnesses in urology. If urosepsis is not diagnosed early, it can rapidly progress and worsen, leading to increased mortality. In recent years, with the increase of urinary tract surgery, the incidence of urosepsis continues to rise, posing a serious threat to patients. Early diagnosis of urosepsis, timely and effective treatment can greatly reduce the mortality of patients. Biomarkers such as WBC, NLR, PCT, IL-6, CRP, lactate, and LncRNA all play specific roles in the early diagnosis or prognosis of urosepsis. In addition to the abnormal increase of WBC, we should be more alert to the rapid decline of WBC. NLR values were superior to WBC counts alone in predicting infection severity. Compared with several other biomarkers, PCT values can differentiate between bacterial and non-bacterial sepsis. IL-6 always has high sensitivity and specificity for the diagnosis of sepsis, and CRP also has high sensitivity and specificity for the diagnosis of urosepsis. Lactic acid is closely related to the prognosis of patients with urosepsis. LncRNAs may be potential biomarkers of urosepsis. This article summarizes the main biomarkers, hoping to provide a reference for the timely diagnosis and evaluation of urosepsis.
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spelling pubmed-98934022023-02-03 Diagnostic and therapeutic value of biomarkers in urosepsis Wu, Yuyun Wang, Guang Huang, Ziye Yang, Bowei Yang, Tongxin Liu, Jianhe Li, Pei Li, Jiongming Ther Adv Urol Review Urosepsis is sepsis caused by urogenital tract infection and is one of the most common critical illnesses in urology. If urosepsis is not diagnosed early, it can rapidly progress and worsen, leading to increased mortality. In recent years, with the increase of urinary tract surgery, the incidence of urosepsis continues to rise, posing a serious threat to patients. Early diagnosis of urosepsis, timely and effective treatment can greatly reduce the mortality of patients. Biomarkers such as WBC, NLR, PCT, IL-6, CRP, lactate, and LncRNA all play specific roles in the early diagnosis or prognosis of urosepsis. In addition to the abnormal increase of WBC, we should be more alert to the rapid decline of WBC. NLR values were superior to WBC counts alone in predicting infection severity. Compared with several other biomarkers, PCT values can differentiate between bacterial and non-bacterial sepsis. IL-6 always has high sensitivity and specificity for the diagnosis of sepsis, and CRP also has high sensitivity and specificity for the diagnosis of urosepsis. Lactic acid is closely related to the prognosis of patients with urosepsis. LncRNAs may be potential biomarkers of urosepsis. This article summarizes the main biomarkers, hoping to provide a reference for the timely diagnosis and evaluation of urosepsis. SAGE Publications 2023-01-31 /pmc/articles/PMC9893402/ /pubmed/36744043 http://dx.doi.org/10.1177/17562872231151852 Text en © The Author(s), 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Wu, Yuyun
Wang, Guang
Huang, Ziye
Yang, Bowei
Yang, Tongxin
Liu, Jianhe
Li, Pei
Li, Jiongming
Diagnostic and therapeutic value of biomarkers in urosepsis
title Diagnostic and therapeutic value of biomarkers in urosepsis
title_full Diagnostic and therapeutic value of biomarkers in urosepsis
title_fullStr Diagnostic and therapeutic value of biomarkers in urosepsis
title_full_unstemmed Diagnostic and therapeutic value of biomarkers in urosepsis
title_short Diagnostic and therapeutic value of biomarkers in urosepsis
title_sort diagnostic and therapeutic value of biomarkers in urosepsis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893402/
https://www.ncbi.nlm.nih.gov/pubmed/36744043
http://dx.doi.org/10.1177/17562872231151852
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