A rare case report of waldenström macroglobulinemia converted to serum low IgM

Waldenström Macroglobulinemia (WM) is a rare chronic lymphoproliferative disease, accounting for less than 2% of hematological malignancies. It is characterized by plasma cytoid lymphocyte infiltration in bone marrow and abnormal increase of monoclonal IgM in peripheral blood. Only 5%–10% of cases o...

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Autores principales: Xiang, Yuan, Fang, Shi-Qiang, Liu, Yi-Wen, Wang, Hui, Lu, Zhong-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893496/
https://www.ncbi.nlm.nih.gov/pubmed/36744182
http://dx.doi.org/10.3389/fgene.2022.1051917
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author Xiang, Yuan
Fang, Shi-Qiang
Liu, Yi-Wen
Wang, Hui
Lu, Zhong-Xin
author_facet Xiang, Yuan
Fang, Shi-Qiang
Liu, Yi-Wen
Wang, Hui
Lu, Zhong-Xin
author_sort Xiang, Yuan
collection PubMed
description Waldenström Macroglobulinemia (WM) is a rare chronic lymphoproliferative disease, accounting for less than 2% of hematological malignancies. It is characterized by plasma cytoid lymphocyte infiltration in bone marrow and abnormal increase of monoclonal IgM in peripheral blood. Only 5%–10% of cases of WM secrete monoclonal IgG and IgA components or do not secrete monoclonal long immunoglobulin. This case is the first to report of serum protein recombination from lgM and Igkappa band mutation to abnormal lgG and Igkappa band after 6 years of treatment in a male patient with WM.
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spelling pubmed-98934962023-02-03 A rare case report of waldenström macroglobulinemia converted to serum low IgM Xiang, Yuan Fang, Shi-Qiang Liu, Yi-Wen Wang, Hui Lu, Zhong-Xin Front Genet Genetics Waldenström Macroglobulinemia (WM) is a rare chronic lymphoproliferative disease, accounting for less than 2% of hematological malignancies. It is characterized by plasma cytoid lymphocyte infiltration in bone marrow and abnormal increase of monoclonal IgM in peripheral blood. Only 5%–10% of cases of WM secrete monoclonal IgG and IgA components or do not secrete monoclonal long immunoglobulin. This case is the first to report of serum protein recombination from lgM and Igkappa band mutation to abnormal lgG and Igkappa band after 6 years of treatment in a male patient with WM. Frontiers Media S.A. 2023-01-19 /pmc/articles/PMC9893496/ /pubmed/36744182 http://dx.doi.org/10.3389/fgene.2022.1051917 Text en Copyright © 2023 Xiang, Fang, Liu, Wang and Lu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Xiang, Yuan
Fang, Shi-Qiang
Liu, Yi-Wen
Wang, Hui
Lu, Zhong-Xin
A rare case report of waldenström macroglobulinemia converted to serum low IgM
title A rare case report of waldenström macroglobulinemia converted to serum low IgM
title_full A rare case report of waldenström macroglobulinemia converted to serum low IgM
title_fullStr A rare case report of waldenström macroglobulinemia converted to serum low IgM
title_full_unstemmed A rare case report of waldenström macroglobulinemia converted to serum low IgM
title_short A rare case report of waldenström macroglobulinemia converted to serum low IgM
title_sort rare case report of waldenström macroglobulinemia converted to serum low igm
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893496/
https://www.ncbi.nlm.nih.gov/pubmed/36744182
http://dx.doi.org/10.3389/fgene.2022.1051917
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